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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제4호
- 발행연도
- 2018.1
- 수록면
- 597 - 605 (9page)
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초록· 키워드
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Acyl-CoA oxidases (ACOXs) play important roles in lipid metabolism, including peroxisomal fatty acid β-oxidation by the conversion of acyl-CoAs to 2-trans-enoyl-CoAs. The yeast Yarrowia lipolytica can utilize fatty acids as a carbon source and thus has extensive biotechnological applications. The crystal structure of ACOX3 from Y. lipolytica (YlACOX3) was determined at a resolution of 2.5 Å. It contained two molecules per asymmetric unit, and the monomeric structure was folded into four domains; Nα, Nβ, Cα1, and Cα2 domains. The cofactor flavin adenine dinucleotide was bound in the dimer interface. The substrate-binding pocket was located near the cofactor, and formed at the interface between the Nα, Nβ, and Cα1 domains. Comparisons with other ACOX structures provided structural insights into how YlACOX has a substrate preference for short-chain acyl-CoA. In addition, the structure of YlACOX3 was compared with those of medium- and long-chain ACOXs, and the structural basis for their differences in substrate specificity was discussed.
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참고문헌 (46)
참고문헌 신청
Kunau WH / 1995 / Beta-oxidation of fatty acids in mitochondria, peroxisomes, and bacteria: a century of continued progress / Prog. Lipid Res. 34:267~342
Hiltunen JK / 2000 / Beta-oxidation - strategies for the metabolism of a wide variety of acyl-CoA esters / Biochim. Biophys. Acta 1484:117~128
Poirier Y / 2006 / Peroxisomal beta-oxidation - a metabolic pathway with multiple functions / Biochim. Biophys. Acta 1763:1413~1426
Hashimoto T / 1999 / Peroxisomal $\beta$ -oxidation enzymes / Neurochem. Res. 24:551~563
Nakajima Y / 2002 / Three-dimensional structure of the flavoenzyme acyl-CoA oxidase-II from rat liver, the peroxisomal counterpart of mitochondrial acyl-CoA dehydrogenase / J. Biochem. 131:365~374
Hiltunen JK / 2000 / Beta-oxidation - strategies for the metabolism of a wide variety of acyl-CoA esters / Biochim. Biophys. Acta 1484:117~128
Poirier Y / 2006 / Peroxisomal beta-oxidation - a metabolic pathway with multiple functions / Biochim. Biophys. Acta 1763:1413~1426
Hashimoto T / 1999 / Peroxisomal
Nakajima Y / 2002 / Three-dimensional structure of the flavoenzyme acyl-CoA oxidase-II from rat liver, the peroxisomal counterpart of mitochondrial acyl-CoA dehydrogenase / J. Biochem. 131:365~374
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