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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제19권 제12호
- 발행연도
- 2009.1
- 수록면
- 1,520 - 1,526 (7page)
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We have identified the iscR (PA3815) gene encoding an
iron-sulfur cluster assembly regulator homolog as one of
the genes required for peroxide resistance in Pseudomonas
aeruginosa PA14. Here, we present the phenotypic
characterization of an iscR deletion mutant in terms of
KatA expression, stress responses, and virulence. The
iscR null mutant exhibited reduced KatA activity at the
posttranslational level, hypersensitivity to hydrogen peroxide,
and virulence-attenuation in Drosophila melanogaster and
mouse peritonitis models. These phenotypes were fully
restored by multicopy-based expression of katA. These results
suggest that the requirement of IscR in P. aeruginosa is
related to the proper activity of KatA, which is crucial for
peroxide resistance and full virulence of this bacterium.
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참고문헌 (22)
참고문헌 신청
Agar, J. N. / 2000 / IscU as a scaffold for iron-sulfur cluster biosynthesis: Sequential assembly of [2Fe-2S] and [4Fe-4S] clusters in IscU / Biochemistry 39 : 7856 ~ 7862
Becher, A. / 2000 / Integration-proficient Pseudomonas aeruginosa vectors for isolation of single-copy chromosomal lacZ and lux gene fusions / Biotechniques 29 : 948 ~ 950
CHOI, YOUNG-SEOK / 2007 / Identification of Pseudomonas aeruginosa Genes Crucial for Hydrogen PeroxideResistance / Journal of Microbiology and Biotechnology 17 (8) : 1344 ~ 1
Dean, R. T. / 1997 / Biochemistry and pathology of radical-mediated protein oxidation / Biochem. J 324 : 1 ~ 18
Deisseroth, A. / 1970 / Catalase: Physical and chemical properties, mechanism of catalysis, and physiological role / Physiol. Rev 50 : 319 ~ 375
Becher, A. / 2000 / Integration-proficient Pseudomonas aeruginosa vectors for isolation of single-copy chromosomal lacZ and lux gene fusions / Biotechniques 29 : 948 ~ 950
CHOI, YOUNG-SEOK / 2007 / Identification of Pseudomonas aeruginosa Genes Crucial for Hydrogen PeroxideResistance / Journal of Microbiology and Biotechnology 17 (8) : 1344 ~ 1
Dean, R. T. / 1997 / Biochemistry and pathology of radical-mediated protein oxidation / Biochem. J 324 : 1 ~ 18
Deisseroth, A. / 1970 / Catalase: Physical and chemical properties, mechanism of catalysis, and physiological role / Physiol. Rev 50 : 319 ~ 375
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