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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제1호
- 발행연도
- 2008.1
- 수록면
- 145 - 152 (8page)
이용수
초록· 키워드
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A cell-based in vitro exposure system was developed to
determine whether oxidative stress plays a role in the
cytotoxic effects of volatile organic compounds (VOCs)
such as benzene, toluene, xylene, and chlorobenzene, using
human epithelial HeLa cells. Thin films based on cysteineterminated
synthetic oligopeptides were fabricated for
immobilization of the HeLa cells on a gold (Au) substrate.
In addition, an immobilized cell-based sensor was applied
to the electrochemical detection of the VOCs. Layer
formation and immobilization of the cells were investigated
with surface plasmon resonance (SPR), cyclic voltammetry
(CV), and electrochemical impedance spectroscopy (EIS).
The adhered living cells were exposed to VOCs; this
caused a change in the SPR angle and the VOC-specific
electrochemical signal. In addition, VOC toxicity was found
to correlate with the degree of nitric oxide (NO) generation
and EIS. The primary reason for the marked increase in
impedance was the change of aqueous electrolyte composition
as a result of cell responses. The p53 and NF-κB
downregulation were closely related to the magnitude of
growth inhibition associated with increasing concentrations
of each VOC. Therefore, the proposed cell immobilization
method, using a self-assembly technique and VOC-specific
electrochemical signals, can be applied to construct a cell
microarray for onsite VOC monitoring.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Bai, P. / 2001 / Partial protection by poly(ADP-ribose) polymerase inhibitors from nitroxyl-induced cytotoxity in thymocytes. Free Radic. Biol / Med 31 : 1616 ~ 1623
Beckman, J. S. / 1990 / Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad / Sci 87
Beda, N. / 2005 / A spectrophotometric assay for nitrate in an excess of nitrite / Nitric Oxide 13 : 93 ~ 97
Blackwell, T. S. / 1997 / The role of nuclear factor-kB in cytokine gene regulation. Am. J. Respir. Cell Mol / Biol 17 : 3 ~ 9
Bosca, L. / 2005 / Nitric oxide and cell viability in inflammatory cells, a role for NO in macrophage function and fate / Toxicology 208 : 249 ~ 258
Beckman, J. S. / 1990 / Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad / Sci 87
Beda, N. / 2005 / A spectrophotometric assay for nitrate in an excess of nitrite / Nitric Oxide 13 : 93 ~ 97
Blackwell, T. S. / 1997 / The role of nuclear factor-kB in cytokine gene regulation. Am. J. Respir. Cell Mol / Biol 17 : 3 ~ 9
Bosca, L. / 2005 / Nitric oxide and cell viability in inflammatory cells, a role for NO in macrophage function and fate / Toxicology 208 : 249 ~ 258
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