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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제16권 제4호
- 발행연도
- 2006.1
- 수록면
- 590 - 596 (7page)
이용수
초록· 키워드
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Clavulanic acid (CA) produced by Streptomycesclavuligerus is degraded during the bacterial cultivation. Thephysical, chemical, and enzymatic effects, in order to understandthe degradation during the cultivation. The result showed that CAwas unstable in the production medium containing amoniumsalts and amino acids, owing to amonium ions and aminegroups. In addition, the degradation was not only due to instabilityof CA by metabolites and proteins, but also enzymes from S.clavuligerus such as β-lactamase and penicillin-binding proteins.However, the degradation caused by these enzymes was not highlysignificant compared with the degradation during the cultivation,
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참고문헌 (18)
참고문헌 신청
Alexander, D. C / 1998 / Investigation of the Streptomyces clavuligerus cephamycin C gene cluster and its regulation by the CcaR protein / J. Bacteriol. 180 : 4068 ~ 4079
Andrietta, M. G. S / 1997 / Selection of industrial complex medium for cephalosporin C production / J. Brazilian Soc. Microbiol. 28 : 109 ~ 113
Doran, J. L / 1990 / Isolation and characterization of a β-lactamase-inhibitory protein from Streptomyces clavuligerus and cloning and analysis of the corresponding gene / J
Haginaka, J / 1981 / Stability of clavulanic acid in aqueous solutions / Chem. Pharm. Bull. 29 : 3334 ~ 3341
Jensen, S. E / 2004 / Five additional genes are involved in clavulanic acid biosynthesis in Streptomyces clavuligerus / Antimicrob. Agents Chemother. 48 : 192 ~ 202
Andrietta, M. G. S / 1997 / Selection of industrial complex medium for cephalosporin C production / J. Brazilian Soc. Microbiol. 28 : 109 ~ 113
Doran, J. L / 1990 / Isolation and characterization of a β-lactamase-inhibitory protein from Streptomyces clavuligerus and cloning and analysis of the corresponding gene / J
Haginaka, J / 1981 / Stability of clavulanic acid in aqueous solutions / Chem. Pharm. Bull. 29 : 3334 ~ 3341
Jensen, S. E / 2004 / Five additional genes are involved in clavulanic acid biosynthesis in Streptomyces clavuligerus / Antimicrob. Agents Chemother. 48 : 192 ~ 202
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