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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제20권 제4호
- 발행연도
- 2010.1
- 수록면
- 821 - 827 (7page)
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초록· 키워드
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Gene delivery that provides targeted delivery of therapeutic genes to the cells of a lesion enhances therapeutic efficacy and reduces toxic side effects. This process is especially important in cancer therapy when it is advantageous to avoid unwanted damage to healthy normal cells.
Incorporating cancer-specific ligands that recognize receptors overexpressed on cancer cells can increase selective binding and uptake and, as a result, increase targeted transgene expression. In this study, we investigated whether a peptide capable of homing to hepatocellular carcinoma (HCC)could facilitate targeted gene delivery by cationic liposomes.
This homing peptide (HBP) exhibited selective binding to a human hepatocarcinoma cell line, HepG2, at a concentration ranging from 5 to 5,000 nM. When conjugated to a cationic liposome, HBP substantially increased cellular internalization of plasmid DNA to increase the transgene expression in HepG2 cells. In addition, there was no significant enhancement in gene transfer detected for other human cell lines tested, including THLE-3, AD293, and MCF-7cells. Therefore, we demonstrate that HBP provides targeted gene delivery to HCC by cationic liposomes.
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참고문헌 (25)
참고문헌 신청
Asai, T / 2002 / Anti-neovascular therapy by liposomal DPP-CNDAC targeted to angiogenic vessels / FEBS Lett 520 : 167 ~ 170
Connors, T. A / 1995 / The choice of prodrugs for gene directed enzyme prodrug therapy of cancer / Gene Ther 2 : 702 ~ 709
Drozdzik, M / 2000 / Combined gene therapy with suicide gene and interleukin-12 is more efficient than therapy with one gene alone in a murine model of hepatocellular carcino
Duffy, J. P / 2008 / Surgical resection of hepatocellular carcinoma / Cancer J 14 : 100 ~ 110
Escarda, A / 2006 / Clivus metastasis from hepatocarcinoma associated with transarterial hepatic chemoembolization. Gastroenterol / Hepatol 29 : 401 ~ 404
Connors, T. A / 1995 / The choice of prodrugs for gene directed enzyme prodrug therapy of cancer / Gene Ther 2 : 702 ~ 709
Drozdzik, M / 2000 / Combined gene therapy with suicide gene and interleukin-12 is more efficient than therapy with one gene alone in a murine model of hepatocellular carcino
Duffy, J. P / 2008 / Surgical resection of hepatocellular carcinoma / Cancer J 14 : 100 ~ 110
Escarda, A / 2006 / Clivus metastasis from hepatocarcinoma associated with transarterial hepatic chemoembolization. Gastroenterol / Hepatol 29 : 401 ~ 404
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