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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제19권 제3호
- 발행연도
- 2009.1
- 수록면
- 217 - 228 (12page)
이용수
초록· 키워드
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Mobile genetic segments, or transposons, are also referred
to as “jumping genes” as they can shift from one position
in the genome to another, thus inducing a chromosomal
mutation. According to the target site-specificity of the
transposon during a transposition event, the result is either
the insertion of a gene of interest at a specific chromosomal
site, or the creation of knockout mutants. The former
situation includes the integration of conjugative transposons
via site-specific recombination, several transposons preferring
a target site of a conserved AT-rich sequence, and Tn7
being site-specifically inserted at attTn7, the downstream
of the essential glmS gene. The latter situation is exploited
for random mutagenesis in many prokaryotes, including
IS (insertion sequence) elements, mariner, Mu, Tn3 derivatives
(Tn4430 and Tn917), Tn5, modified Tn7, Tn10, Tn552,
and Ty1, enabling a variety of genetic manipulations.
Randomly inserted transposons have been previously employed
for a variety of applications such as genetic footprinting,
gene transcriptional and translational fusion, signaturetagged
mutagenesis (STM), DNA or cDNA sequencing,
transposon site hybridization (TraSH), and scanning linker
mutagenesis (SLM). Therefore, transposon-mediated genetic
engineering is a valuable discipline for the study of
bacterial physiology and pathogenesis in living hosts.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Akerley, B. J. / 1998 / Systematic identification of essential genes by in vitro mariner mutagenesis / Proc. Natl. Acad. Sci. U.S.A. 95 : 8927 ~ 8932
Akerley, B. J. / 2002 / A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae / Proc. Natl. Acad. Sci. U.S.A. 99 : 966
Albano, M. A. / 1992 / phoA gene fusions in Legionella pneumophila generated in vivo using a new transposon, MudphoA / Mol. Microbiol 6 : 1829 ~ 1839
Badarinarayana, V. / 2001 / Selection analyses of insertional mutants using subgenic resolution arrays / Nat. Biotechnol 19 : 1060 ~ 1065
Bainton, R. J. / 1993 / Tn7 transposition: Target DNA recognition is mediated by multiple Tn7-encoded proteins in a purified in vitro system / Cell 72 : 931 ~ 943
Akerley, B. J. / 2002 / A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae / Proc. Natl. Acad. Sci. U.S.A. 99 : 966
Albano, M. A. / 1992 / phoA gene fusions in Legionella pneumophila generated in vivo using a new transposon, MudphoA / Mol. Microbiol 6 : 1829 ~ 1839
Badarinarayana, V. / 2001 / Selection analyses of insertional mutants using subgenic resolution arrays / Nat. Biotechnol 19 : 1060 ~ 1065
Bainton, R. J. / 1993 / Tn7 transposition: Target DNA recognition is mediated by multiple Tn7-encoded proteins in a purified in vitro system / Cell 72 : 931 ~ 943
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