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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제14권 제1호
- 발행연도
- 2004.1
- 수록면
- 121 - 127 (7page)
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초록· 키워드
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Amphotericin B (AmB), an amphipathic polyenemacrolide, is an antifungal drug produced by Streptomycesnodosus. Recently, AmB has been shown to exert antiviralactivity against rubella virus and human immunodeficiencyvirus by different mechanisms. In this study, we evaluated theantiviral effect of AmB against Japanese encephalitis virus(JEV) and investigated which step of the viral life cycle wasinhibited by AmB to understand the mechanism of antiviralaction of AmB. AmB reduced both plaque size and number inthe infected cells in a dose-dependent manner. In addition, a200-fold reduction of infectious virus titer was observed bytreatment of infected cells with 5 mg/ml of AmB. AmB actedat the post virus-infection step, but not during adsorption ofvirus to host cells. Western blot analysis revealed that theaccumulated level of JEV envelope protein dramatically decreasedin the infected cells by treatment with 5- 10 mg/ml of AmB.Our results indicate that AmB inhibits the replication of JEVat the postinfection step by interfering with viral replicationand/or by inhibiting the synthesis of viral proteins.
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참고문헌 (18)
참고문헌 신청
/ 1981 / Effects of amphotericin B on hepatitisB virus : 826 ~ 833
/ 1986 / Mode of action of clinically importantantifungal drugs Inhibition of JEV envelope protein synthesis by AmB Crude cell lysates from BHK-21 cells mock-infected infect
/ 1993 / Lipidcomposition and fluidity of the human immunodeficiencyvirus envelope and host cell plasma membranes : 5181 ~ 90 5185
/ 1995 / AmphotericinB derivative blocks human immunodeficiency virus type 1entry after CD4 binding Effect on virus-cell fusion but noton cell-cell fusion 69 : 570 ~ 574
/ 1996 / Flaviviridae: the viruses and theirreplication, pp. 931-959. In B. N. Fields, D. M. Knipe, and P. M. Howley (eds.), Fields Virology, 3rd ed : 931 ~ 959
/ 1986 / Mode of action of clinically importantantifungal drugs Inhibition of JEV envelope protein synthesis by AmB Crude cell lysates from BHK-21 cells mock-infected infect
/ 1993 / Lipidcomposition and fluidity of the human immunodeficiencyvirus envelope and host cell plasma membranes : 5181 ~ 90 5185
/ 1995 / AmphotericinB derivative blocks human immunodeficiency virus type 1entry after CD4 binding Effect on virus-cell fusion but noton cell-cell fusion 69 : 570 ~ 574
/ 1996 / Flaviviridae: the viruses and theirreplication, pp. 931-959. In B. N. Fields, D. M. Knipe, and P. M. Howley (eds.), Fields Virology, 3rd ed : 931 ~ 959
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