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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제14권 제5호
- 발행연도
- 2004.1
- 수록면
- 972 - 977 (6page)
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The hypoglycemic effect of an exo-biopolymer(EXO) and endo-biopolymer (ENDO) produced from submergedmycelial culture of Ganoderma lucidum was investigated instreptozotocin (STZ)-induced diabetic rats. Both the EXOand ENDO showed hypoglycemic potential, however, theformer proved to be more potent than the latter. Theadministration of the EXO at the dose of 100 mg/kg bodyweight (BW) significantly reduced the plasma glucose level(23.5%) and increased the plasma insulin level (2.2 fold) inthe diabetic animals. The EXO also lowered the plasmatotal cholesterol, triglyceride, low-density lipoprotein (LDL)cholesterol, and athrogenic index by 14.7, 31.4, 24.1, and45.4%, respectively, and reduced the liver total cholesteroland triglyceride levels by 6.7 and 25.8%, respectively. Itincreased the plasma high-density lipoprotein (HDL) cholesterol(37.7%), compared to the control group. Furthermore, thealanine transaminase (ALT) and aspartate transaminase (AST)showed lower activities in the EXO administered groups thanthe other experimental groups. Taken together, these resultssuggest that the exo-biopolymer may alleviate the bloodglucose level by increased insulin secretion.
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참고문헌 (30)
참고문헌 신청
/ 1971 / Use ofpolyethylene glycol to separate free and antibody-boundpeptide hormones in radioimmunoassays : 732 ~ 738
Bierman / 1992 / Atherogenesis in diabetes : 647 ~ 656
Bursch / 1986 / Cytoprotectiveeffect of the prostacyclin derivative iloprost against liver celldeath induced by the hepatotoxins carbon terachloride andbromobenzen : 47 ~ 50
Duncan,D.M / 1957 / Multiple-range tests for correlated andheteroscedastic means 13 : 164 ~ 170
Foster / 1983 / The metabolicderangements and treatment of diabetic ketoacidosis : 159 ~ 164
Bierman / 1992 / Atherogenesis in diabetes : 647 ~ 656
Bursch / 1986 / Cytoprotectiveeffect of the prostacyclin derivative iloprost against liver celldeath induced by the hepatotoxins carbon terachloride andbromobenzen : 47 ~ 50
Duncan,D.M / 1957 / Multiple-range tests for correlated andheteroscedastic means 13 : 164 ~ 170
Foster / 1983 / The metabolicderangements and treatment of diabetic ketoacidosis : 159 ~ 164
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