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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 33 - 41 (9page)
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TBX21 (T-bet) is a member of the T-box family of transcriptional
factors that contain a conserved DNA binding
domain. TBX21 is a critical regulator of the commitment
to the Th1 lineage and IFN-γ production. Th1 and
Th2 cells cross-regulate the differentiation of each other,
and in this way TBX21 could be an attractive candidate
gene for treating autoimmune disease such as
rheumatoid arthritis (RA). In present study, we analyzed
the genotypic frequencies of six polymorphisms
of the TBX21 gene between the 367 RA patients and the
572 healthy controls. We showed that the g.-1514T＞C
and c.99C＞G polymorphisms are suggestively associated
with RA susceptibility. It is interesting that the
genotypic frequencies of the TBX21 polymorphisms
(g.-1514T＞C and c.2103A＞C) in the male RA patients
were significantly different from the male control
group (P = 0.0016 and 0.045, respectively). We also
found that the g.-1514T＞C and c.2103A＞C polymorphisms
of the TBX21 gene in the male RA patients
have significant association with the levels of anti-CCP (P = 0.05) and rheumatoid factor (P = 0.03), respectively.
These results suggest that the polymorphisms
of the TBX21 gene might be associated with the susceptibility
to male RA patients.
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참고문헌 (23)
참고문헌 신청
Abbas AK / 1996 / Functional diversity of helper T lymphocytes / Nature 383 : 787 ~ 793
Akahoshi M / 2005 / Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma / Hum Genet 117 : 16 ~ 26
Baeten D / 2001 / Specific presence of intracellular citrullinated proteins in rheumatoid arthritis synovium: relevance to antifilaggrin autoantibodies / Arthritis Rheum 44 :
Chae SC / 2004 / The exon 4 variations of Tim-1 gene are associated with rheumatoid arthritis in a Korean population / Biochem Biophys Res Commun 315 : 971 ~ 975
Chae SC / 2005 / Eotaxin-3 gene polymorphisms are associated with rheumatoid arthritis in a Korean population / Hum Immunol 66 : 314 ~ 320
Akahoshi M / 2005 / Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma / Hum Genet 117 : 16 ~ 26
Baeten D / 2001 / Specific presence of intracellular citrullinated proteins in rheumatoid arthritis synovium: relevance to antifilaggrin autoantibodies / Arthritis Rheum 44 :
Chae SC / 2004 / The exon 4 variations of Tim-1 gene are associated with rheumatoid arthritis in a Korean population / Biochem Biophys Res Commun 315 : 971 ~ 975
Chae SC / 2005 / Eotaxin-3 gene polymorphisms are associated with rheumatoid arthritis in a Korean population / Hum Immunol 66 : 314 ~ 320
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