지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 613 - 621 (9page)
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Although the genetic component in the etiology of rheumatoid arthritis (RA) has been consistently suggested,many novel genetic loci remain to uncover. To identify RA risk loci, we performed a genome-wide association study (GWAS) with 100 RA cases and 600controls using Affymetrix SNP array 5.0. The candidate risk locus (APOM gene) was re-sequenced to discover novel promoter and coding variants in a group of the subjects. Replication was performed with the independent case-control set comprising of 578 RAs and 711 controls. Through GWAS, we identified a novel SNP associated with RA at the APOM gene in the MHC class III region on 6p21.33 (rs805297, odds ratio (OR)= 2.28, P = 5.20 × 10-7). Three more polymorphisms were identified at the promoter region of the APOM by the re-sequencing. For the replication, we genotyped the four SNP loci in the independent case-control set.
The association of rs805297 identified by GWAS was successfully replicated (OR = 1.40, P = 6.65 × 10-5).
The association became more significant in the combined analysis of discovery and replication sets (OR =1.56, P = 2.73 × 10-10). The individuals with the rs805297 risk allele (A) at the promoter region showed a significantly lower level of APOM expression compared with those with the protective allele (C)homozygote. In the logistic regressions by the phenotype status, the homozygote risk genotype (A/A) consistently showed higher ORs than the heterozygote one (A/C) for the phenotype-positive RAs. These results indicate that APOM promoter polymorphisms are significantly associated with the susceptibility to RA.
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참고문헌 (24)
참고문헌 신청
Arnett FC / 1988 / The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis / Arthritis Rheum 31 : 315 ~ 324
Burger D / 2002 / High-density lipoprotein-associated apolipoprotein A-I: the missing link between infection, chronic inflammation / Autoimmun Rev 1 : 111 ~ 117
Choy E / 2009 / Interpreting lipid levels in the context of high-grade inflammatory states with a focus on rheumatoid arthritis: a challenge to conventional cardiovascular ri
Dempster A / 1977 / Maximum likelihood from incomplete data via the EM algorithm / J R Stat Soc Series B Stat Method 39 : 1 ~ 38
Feingold KR / 2008 / Infection and inflammation decrease apolipoprotein M expression / Atherosclerosis 199 : 19 ~ 26
Burger D / 2002 / High-density lipoprotein-associated apolipoprotein A-I: the missing link between infection, chronic inflammation / Autoimmun Rev 1 : 111 ~ 117
Choy E / 2009 / Interpreting lipid levels in the context of high-grade inflammatory states with a focus on rheumatoid arthritis: a challenge to conventional cardiovascular ri
Dempster A / 1977 / Maximum likelihood from incomplete data via the EM algorithm / J R Stat Soc Series B Stat Method 39 : 1 ~ 38
Feingold KR / 2008 / Infection and inflammation decrease apolipoprotein M expression / Atherosclerosis 199 : 19 ~ 26
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