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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 614 - 620 (7page)
이용수
초록· 키워드
오류제보하기
Endothelin (ET) receptor antagonists have been developed
to produce a reduction of ET related effects in various
diseases, as well as in animal models of airway
inflammation. We aimed to investigate the anti-inflammatory
potential of bosentan on a rat model of
emphysema. Thirty Wistar male rats were classified as
control group (group 1), intratracheally (i.t.) instilled
with saline, treated with vehicle solution; elastase
group (group 2), i.t. instilled with porcine pancreatic
elastase (PPE), treated with vehicle solution; and
PPE+bosentan group (group 3), i.t. instilled with PPE,
treated with bosentan. The levels of TNF-α, IL-1β, IL-6,
and IL-8 in bronchoalveolar lavage fluid (BALF) and
lung tissue, cell counts in BALF, and histologic analysis
of all groups were evaluated. Neutrophile granulocytes
(NG) and alveolar macrophages (AM) were increased
more in group 2 than in group 1 (P ＜ 0.001, P
= 0.04, respectively). Compared with group 2, neutrophil
granulocyte (NG) and alveolar macrophages
(AM) counts were decreased in group 3 (P ＜ 0.001).
Histological examination confirmed a diffuse neutrophilic
inflammation and irregular alveolar air space
enlargement in group 2. Treatment with bosentan partially
reduced the enlarged lung volumes. Compared
with group 1, the BALF levels of TNF-α and IL-6, and the lung tissue levels of IL-1β, IL-6, and IL-8 were increased
in group 2 (P = 0.028, P = 0.005, P = 0.001, P =
0.019, P ＜ 0.001, respectively). The TNF-α and IL-8
levels of BALF (P = 0.007, P = 0.001, respectively), and
the TNF-α, IL-1β, IL-6, and the IL-8 levels of lung tissue
(P = 0.031, P = 0.017, P = 0.007, P ＜ 0.001) were decreased
in group 3 compared to group 2. In conclusion,
bosentan decreased the inflammatory response by reducing
numbers of inflammatory cells and proinflammatory
cytokines.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
/ 2007 / 620 Exp 39 (5) : 614 ~ 620
Anthoni C / 2006 / bosentan, an endothelin receptor antagonist, reduces leucocyte adhesion and inflammation in a murine model of in-flammatory bowel disease 21 : 409 ~ 418
Blackwell TS / / Cytokine-induced neutrophil chemoattrac-tant mediates neutrophilic alveolitis in rats association with nuclear factor kapa B activation : 464 ~ 72
Breu V / jpharmacolexpther1994;270 / Pha-rmacological characterization of bosentan : 228 ~ 35
Cantor JO / 1998 / Aerosolized hyaluronic acid decreases alveolar injury induced by human neutrophil elastase 217 ( ) : 471 ~ 475
Anthoni C / 2006 / bosentan, an endothelin receptor antagonist, reduces leucocyte adhesion and inflammation in a murine model of in-flammatory bowel disease 21 : 409 ~ 418
Blackwell TS / / Cytokine-induced neutrophil chemoattrac-tant mediates neutrophilic alveolitis in rats association with nuclear factor kapa B activation : 464 ~ 72
Breu V / jpharmacolexpther1994;270 / Pha-rmacological characterization of bosentan : 228 ~ 35
Cantor JO / 1998 / Aerosolized hyaluronic acid decreases alveolar injury induced by human neutrophil elastase 217 ( ) : 471 ~ 475
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