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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 594 - 602 (9page)
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To investigate the mechanism by which the C-terminus (4,938-5,037) of the ryanodine receptor 1 (RyR1) ho-mo-tetramerizes, forming a functional Ca2+-release channel, the structural requirements for the tetrameri-zation were studied using site-directed mutagenesis. H5003, D5026, E5033 and D5034, significantly de-creased the formation of homo-dimers (reduced by ＞ 50%). Interaction between the C-terminus and cyto-plasmic loop I (4,821-4,835) required two positively charged residues, H4832 and K4835. Based on the pre-dicted protein secondary structures, all seven charged residues are located in random coils. Paired ala-nine-substitutions at six negatively charged residues (E4942A/D4953A, D4945A/E4952A and E4948A/ E4955A) of the α-helix (4,940-4,956) in the C-terminus increased homo-dimerization. Therefore, the ho-mo-tetramerization of RyR1 may be mediated by intra- and/or inter-monomer electrostatic interactions among the C-terminal charged residues in random coils or in an α-helix.
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참고문헌 (19)
참고문헌 신청
/ 2007 / 602 Exp 39 (5) : 594 ~ 602
Bixby KA / 1999 / Zn2+-binding and molecular deter-minants of tetramerization in voltage-gated K+channels 6 : 38 ~ 43
Chen SR / 2002 / Role of the proposed pore-forming segment of the Ca 2+ release channel (ryanodine receptor) in ryanodine interaction 82 ( ) : 2436 ~ 2447
Fujii J / / Molecular cloning of cDNAencoding human and rabbit forms of the Ca2+ release channel rya (dine receptor) : 2244 ~ 56
Galvan DL / 1999 / Subunit oligomerization, and topology of the inositol 1,4, 5-trisphos-phate receptor 274 : 29483 ~ 29492
Bixby KA / 1999 / Zn2+-binding and molecular deter-minants of tetramerization in voltage-gated K+channels 6 : 38 ~ 43
Chen SR / 2002 / Role of the proposed pore-forming segment of the Ca 2+ release channel (ryanodine receptor) in ryanodine interaction 82 ( ) : 2436 ~ 2447
Fujii J / / Molecular cloning of cDNAencoding human and rabbit forms of the Ca2+ release channel rya (dine receptor) : 2244 ~ 56
Galvan DL / 1999 / Subunit oligomerization, and topology of the inositol 1,4, 5-trisphos-phate receptor 274 : 29483 ~ 29492
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