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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 288 - 295 (8page)
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초록· 키워드
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Although nickel hypersensitivity is known as a delayed- type hypersensitivity mediated by nickel-specific T cells, it is greatly influenced by other immune cells. Here we show that splenic natural killer cells (NK cells) directly or indirectly respond to nickel by secretion of IFN-γ. Using enzyme-linked immunosorbent spot (ELISPOT) assays, we found that nickel-reactive cells readily secreted IFN-γ when splenocytes were cultured in the presence of varying concentrations of nickel sulfate (NiSO4) for 24 h. However, nickel-reactive IL-2- or IL- 4-secreting cells were infrequent during the 24-h culture with NiSO4. Immune responses to nickel were innate, not adaptive, in nature since the frequency of nickel-reactive IFN-γ-secreting cells did not increase upon previous exposure to NiSO4 and recombination activating gene (RAG)-1-deficient mice contained nickel-reactive IFN-γ-secreting cells. The involvement of NK cells in the innate response to NiSO4 was confirmed since we could observe a significant reduction of the frequency of nickel-reactive cells in NK cell-depleted mice. Furthermore, the number of IFN-γ secreting cells was significantly reduced in the ELISPOT assays when NKG2D was blocked by anti-NKG2D antibody. These results suggest that there is an early and rapid innate immune response to nickel, which is mediated by NK cells and the NKG2D receptor. The significance of the innate response to nickel is that it may contribute to development of the late T cell-mediated delayed type hypersensitivity against nickel.
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참고문헌 (23)
참고문헌 신청
Akira S / 2006 / Pathogen recognition and innate immunity / Cell 124 : 783 ~ 801
Artik S / 2001 / Tolerance to nickel: oral nickel administration induces a high frequency of anergic T cells with persistent suppressor activity / J Immunol 167 : 6794 ~ 6803
Basketter DA / 1993 / Nickel, cobalt and chromium in consumer products: a role in allergic contact dermatitis? / Contact Dermatitis 28 : 15 ~ 25
Budinger L / 2000 / Immunologic mechanisms in hypersensitivity reactions to metal ions: an overview / Allergy 55 : 108 ~ 115
Gamerdinger K / 2003 / A new type of metal recognition by human T cells: contact residues for peptideindependent bridging of T cell receptor and major histocompatibility comp
Artik S / 2001 / Tolerance to nickel: oral nickel administration induces a high frequency of anergic T cells with persistent suppressor activity / J Immunol 167 : 6794 ~ 6803
Basketter DA / 1993 / Nickel, cobalt and chromium in consumer products: a role in allergic contact dermatitis? / Contact Dermatitis 28 : 15 ~ 25
Budinger L / 2000 / Immunologic mechanisms in hypersensitivity reactions to metal ions: an overview / Allergy 55 : 108 ~ 115
Gamerdinger K / 2003 / A new type of metal recognition by human T cells: contact residues for peptideindependent bridging of T cell receptor and major histocompatibility comp
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