지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 213 - 219 (7page)
이용수
초록· 키워드
오류제보하기
Autocrine stimulation via coexpression of hepato-cyte growth factor (HGF) and its receptor (Met) has been reported in many human sarcomas, but few in carcinomas. In this report, we found that one gastric cancer cell line, SNU-484, among 11 gastric cell lines tested has an autocrine HGF- Met stimulation. RT-PCR, ELISA and scatering assay using MDCK cells revealed that SNU-484 cels secreted a significant amount of active HGF (about 1.250.41 ng/24 h/106tioned medium. Resultantly, Met in this cell line was constitutively phosphorylated. Neutralizing antibodies against HGF reduced the tyrosine phosphorylation of Met, resulting in the inhibition of cell proliferation and migration (P＜ 0.005). To the best of our knowledge, this is the first report on autocrine HGF-Met signaling in a gastric cancer cell line. Our observations with SNU-484 cels sugest that HGF is involved in the deve-lopment and/or progresion of some gastric car-cinoma through an autocrine mechanism.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
/ / A broad-spectrum human lung fibroblastderivedmitogen is a variant of hepatocyte growth factor : 415 ~ 9
/ / An epithelial factor released
/ / Invasiveness and metastasis of NIH 3T3 cells induced byMet-hepatocyte growth factor/scatter factor autocrine stimulation : 4731 ~ 5
/ / a paradigm for mesenchymal/epithelial interaction : 1783 ~ 7
/ 1995 / Hepatocyte growth factor and Met receptor expression inhuman pancreatic carcinogenesis : 889 ~ 95
/ / An epithelial factor released
/ / Invasiveness and metastasis of NIH 3T3 cells induced byMet-hepatocyte growth factor/scatter factor autocrine stimulation : 4731 ~ 5
/ / a paradigm for mesenchymal/epithelial interaction : 1783 ~ 7
/ 1995 / Hepatocyte growth factor and Met receptor expression inhuman pancreatic carcinogenesis : 889 ~ 95
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Epigallocatechin-3-gallate inhibits paracrine and autocrine hepatocyte growth factor/scatter factor-induced tumor cell migration and invasion
Experimental and Molecular Medicine
2011 .01
-
Hepatocyte Growth Factor and Met: Molecular Dialogue for Tissue Organization and Repair
Korean journal of biological sciences
1998 .01
-
Transforming variant of Met receptor confers serum independence and anti-apoptotic property and could be involved in the mouse thymic lymphomagenesis
Experimental and Molecular Medicine
2004 .01
-
An alternatively spliced form of Met receptor is tumorigenic
Experimental and Molecular Medicine
2006 .01
-
일부 초등학생의 대표적 신체활동의 에너지소비량 측정 및 에너지소비량과 체중과의 상관성 분석
Journal of Nutrition and Health
2015 .04
-
Regulation of hepatocyte growth factor-mediated urokinase plasminogen activator secretion by MEK/ERK activation in human stomach cancer cell lines
Experimental and Molecular Medicine
2006 .01
-
Rapid Establishment of CHO Cell Lines Producing the Anti-Hepatocyte Growth Factor Antibody SFN68
Journal of Microbiology and Biotechnology
2013 .01
-
Therapeutic effect of hepatocyte growth factor-secreting mesenchymal stem cells in a rat model of liver fibrosis
Experimental and Molecular Medicine
2014 .01
-
Oxidative stress is associated with the number of components of metabolic syndrome: LIPGENE study
Experimental and Molecular Medicine
2013 .01
-
Effects of NSAID's on cell cycle regulation and apoptotic mechanisms in gastric cell line SNU - 16
한국생명과학회 심포지움
2004 .10
-
Suppression of hepatic tumor growth and metastasis by metronomic therapy in a rat model of hepatocellular carcinoma
Experimental and Molecular Medicine
2011 .01
-
VEGF와 HGF에 의해 유도된 U-373-MG 세포의 이동 및 침윤에 미치는 단백질분해효소의 효과
생명과학회지
2016 .10
-
Phosphoproteomic analysis identifies activated MET-axis PI3K/AKT and MAPK/ERK in lapatinib-resistant cancer cell line
Experimental and Molecular Medicine
2013 .01
-
한국 다낭난소증후군 환자에서 대사증후군과 식이 플라보노이드 섭취와의 관련성
Journal of Nutrition and Health
2014 .06
-
Insulin resistance as a key link for the increased risk of cognitive impairment in the metabolic syndrome
Experimental and Molecular Medicine
2015 .01
-
Down-regulation of survivin suppresses uro-plasminogen activator through transcription factor JunB
Experimental and Molecular Medicine
2011 .01
-
Reactive oxygen species regulate the generation of urokinase plasminogen activator in human hepatoma cells via MAPK pathways after treatment with hepatocyte growth factor
Experimental and Molecular Medicine
2009 .01
-
A putative pH-dependent nuclear localization signal in the juxtamembrane region of c-Met
Experimental and Molecular Medicine
2014 .01
-
Xenopus laevis 초기 배의 동물극 분리배양에서 bFGF와 HGF 혼합처리에 의한 기관유도
생명과학회지
2004 .06
-
Progress of antibody-based inhibitors of the HGF–cMET axis in cancer therapy
Experimental and Molecular Medicine
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0