지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 67 - 75 (9page)
이용수
초록· 키워드
오류제보하기
The observation that ascorbate known to retain pro- oxidant properties induces cel death in a number of immortal cell lines, led us to examine its me-chanism and whether it is involved in oxidative stres injury in such asocorbate-enriched tissue cels as hepatocytes. In rat liver homogenates, higher concentrations (1 and 3 mM) of ascorbate suppressed lipid peroxide productions but lower concentrations (0.1 and 0.3 mM) did not. In con-trast to the homogenate, ascorbate increased lipid tion dependant manner. Iso-ascorbate, the epimer of ascorbate did not cause an increase the oxi-dative stress in liver slices. This diferential effect between homogenates and liver slices implies that cellular integrity is required for ascorbate to in-duce oxidative stress. Wortmannin, an inhibitor of the GLUT (glucose transporter) thought to trans-port dehydroascorbate into cels, inhibited [14C]- ascorbate uptake and suppressed oxidative stress in liver slices. Wortmannin suppressed that [14C]- [14C]dehydroascorbate. Taken together, these ob-servations support our hypothesis that ascorbate is oxidized to dehydroascorbate by molecular oxy-gen in solution (i.e., plasma and culture medium) which is then carried into hepatocytes (via a GLUT) where it is reduced back to ascorbate caus-ing oxidative stress.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Effects of glutamate on dehydroascorbate uptake and Its enhanced vulnerability to the peroxidation in cerebral cortical slices
Experimental and Molecular Medicine
2002 .01
-
Macrophage colony-stimulating factor promotes the survival of osteoclast precursors by up-regulating Bcl-XL
Experimental and Molecular Medicine
2002 .01
-
제2형 당뇨병 환자에게 엽산과 아스코르브산 보충이 혈장 호모시스테인 농도와 산화 스트레스에 미치는 영향
한국영양학회지
2009 .03
-
The Role of Cytosolic Ascorbate Peroxidase During Germination and under Oxidative Stress in Hot Pepper
한국동물학회 학술대회
2000 .01
-
Preparation of Conjugated Linoleic Acid Derivatives with Ascorbate
한국생명과학회 심포지움
2005 .04
-
Isolation of Cytosolic Ascorbate Peroxidase Gene and Its Expression in Strawberry
한국식물학회 학술발표대회
2001 .01
-
Tocopherol과 Ascorbate 투여가 사염화탄소로 유도한 흰쥐의 효소활성 및 항산화작용에 미치는 영향 ( The Effect of Tocopherol and Ascorbate on the Enzyme Activity and Antioxidation in CCl4 Induced Rats )
생명과학회지
1999 .06
-
Alteration of Glutathione-Ascorbate Cycle in Tomato Seedlings Exposed to Cadmium
한국동물학회 학술대회
2000 .01
-
Activation of Ascorbate-Glutathione Cycle in Arabidopsis Leaves in Response to Aminotriazole
식물학회지
1998 .01
-
Molecular Cloning and Characterization of a Gene Encoding Hot Pepper Ascorbate Peroxidase
한국동물학회 학술대회
1999 .01
-
노쇠중인 밀 잎에서 scorbate-Glutathione회로 관계 효소의 발달에 대한 Benzyladenine의 효과
식물학회지
1995 .01
-
Differential Antioxidative Responses of Ascorbate-Glutathione Cycle Enzymes and Metabolites to Chromium Stress in Green Gram (Vigna radiata L. Wilczek) Leaves
식물학회지
2006 .01
-
Is the activity of ascorbate peroxidase induced directly by ethylene in cultured soybean (Glycine max) cells\ulcorner
한국동물학회 학술대회
1997 .01
-
Development of Environmental Stress-Tolerant Plants by Gene Manipulation of Antioxidant Enzymes
The Plant Pathology Journal
2001 .04
-
Chlamydomonas reinhardtii에서 정제한 Ascorbate Oxidase의 특성
미생물학회지
1992 .06
-
Streptomyces lavendulae의 균사체 발달에 따른 Ascorbate oxidase 동위효소 양상 변화
미생물학회지
1988 .06
-
Protective effects of Sodium Ascorbate and Mannitol on Bifidobacterium Subjected to Freeze Drying
한국동물학회 학술대회
1996 .01
-
Effect of Benzyladenine on the Enzymes Related to the Ascorbate-Glutathione Pathway in Senescing Wheat Leaves
한국동물학회 학술대회
1994 .01
-
Expression of Cytosolic Ascorbate Peroxidase in Strawberry with Polyploid Genome
한국동물학회 학술대회
1998 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0