지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.1
- 수록면
- 340 - 346 (7page)
이용수
초록· 키워드
오류제보하기
Pro-oxidant properties of ascorbate have been studied with uses of brain tissues and neuronal cels. Here we address potential mechanism of ascorbate coupling with glutamate to generate ox-idative stres, and the role which oxidized as-corbate (dehydroascorbate) transport plays in oxi-dative neuronal injury. Ascorbate in neurones can be depleted by adding glutamate in culture med-ium since endogenous ascorbate can be ex-bate/dehydroascorbate transport by depleting as-corbate in the neurons with the glutamate-heter-oexchange. However, ascorbate is known readily being oxidized to dehydroascorbate in the med-ium. Glutamate enhanced the dehydroascorbate uptake by cels via a glucose transporter (GLUT) from extracelular region, and cytosolic dehydro-ascorbate enhanced lipid peroxide production and reduced glutathione (GSH) concentrations. Iso-as-corbate, the epimer of ascorbate was ineffective in generating the oxidative stress. These obser-vations support the curent concept that the high rates of dehydroascorbate transport via a GLUT after the release of ascorbate by glutamate leads to peroxidation, the role of glutamate on ascor-bate/dehydroascorbate recycling being critical to induce neuronal death via an oxidative stress in the brain injury.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Effects of glutamate on dehydroascorbate uptake and Its enhanced vulnerability to the peroxidation in cerebral cortical slices
Experimental and Molecular Medicine
2002 .01
-
Rapid uptake of oxidized ascorbate induces loss of cellular glutathione and oxidative stress in liver slices
Experimental and Molecular Medicine
2003 .01
-
The Role of Cytosolic Ascorbate Peroxidase During Germination and under Oxidative Stress in Hot Pepper
한국동물학회 학술대회
2000 .01
-
Isolation of Cytosolic Ascorbate Peroxidase Gene and Its Expression in Strawberry
한국식물학회 학술발표대회
2001 .01
-
제2형 당뇨병 환자에게 엽산과 아스코르브산 보충이 혈장 호모시스테인 농도와 산화 스트레스에 미치는 영향
한국영양학회지
2009 .03
-
Development of Environmental Stress-Tolerant Plants by Gene Manipulation of Antioxidant Enzymes
The Plant Pathology Journal
2001 .04
-
Preparation of Conjugated Linoleic Acid Derivatives with Ascorbate
한국생명과학회 심포지움
2005 .04
-
Tocopherol과 Ascorbate 투여가 사염화탄소로 유도한 흰쥐의 효소활성 및 항산화작용에 미치는 영향 ( The Effect of Tocopherol and Ascorbate on the Enzyme Activity and Antioxidation in CCl4 Induced Rats )
생명과학회지
1999 .06
-
Alteration of Glutathione-Ascorbate Cycle in Tomato Seedlings Exposed to Cadmium
한국동물학회 학술대회
2000 .01
-
Activation of Ascorbate-Glutathione Cycle in Arabidopsis Leaves in Response to Aminotriazole
식물학회지
1998 .01
-
Differential Antioxidative Responses of Ascorbate-Glutathione Cycle Enzymes and Metabolites to Chromium Stress in Green Gram (Vigna radiata L. Wilczek) Leaves
식물학회지
2006 .01
-
노쇠중인 밀 잎에서 scorbate-Glutathione회로 관계 효소의 발달에 대한 Benzyladenine의 효과
식물학회지
1995 .01
-
Expression of Cytosolic Ascorbate Peroxidase in Strawberry with Polyploid Genome
한국동물학회 학술대회
1998 .01
-
Molecular Cloning and Characterization of a Gene Encoding Hot Pepper Ascorbate Peroxidase
한국동물학회 학술대회
1999 .01
-
Purification and Characterization of Dehydroascorbate Reductase from Pleurotus ostreatus
The Journal of Microbiology
1998 .09
-
Biochemical Characterization of Transgenic Tobacco Plants That Express a Human Dehydroascorbate Reductase
한국식물학회 학술발표대회
2000 .01
-
Chlamydomonas reinhardtii에서 정제한 Ascorbate Oxidase의 특성
미생물학회지
1992 .06
-
Is the activity of ascorbate peroxidase induced directly by ethylene in cultured soybean (Glycine max) cells\ulcorner
한국동물학회 학술대회
1997 .01
-
Protective effects of Sodium Ascorbate and Mannitol on Bifidobacterium Subjected to Freeze Drying
한국동물학회 학술대회
1996 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0