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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 553 - 558 (6page)
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The eotaxin gene family (eotaxin, eotaxin-2 and eotaxin-3) have been implicated in the recruitment of lymphocytes that is a central aspect of allergic disease. We previously suggested that Eo2 +179T＞ C and Eo2 +275C＞T of the eotaxin-2, and Eo3 +2497T＞G of the eotaxin-3 were significantly as-sociated with susceptibility to asthma. To determine whether the single nucleotide polymorphisms (SNPs) of eotaxin-2 and eotaxin-3 gene family are associated with the susceptibility of ulcerative colitis (UC), we analyzed the genotype of 119 patients with UC and 303 controls using single-base extension (SBE) method. We also calculated the haplotype frequencies among Eo2 + 179T＞C and Eo2 +275C ＞T of the eotaxin-2 and Eo3 +2497T＞G of the eotaxin-3 in both control and UC patients. The genotype frequency of Eo2 +179T＞C and Eo2 +275C＞T between UC patients and controls were significantly different (P= 0.006 and 0.022, respec-tively). The genotype and allele frequencies of EoA2497T＞G in UC patients were not significantly different from those in the controls without UC patients. Our resu Eo2 +179T＞C and Eo2 +275C＞T of eotaxin-2 might be associated with the susceptibility of UC.
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참고문헌 (24)
참고문헌 신청
/ / Breuer R. Eotaxin-3 butnot eotaxin gene expression is upregulated in asthmatics 24hours after allergen challenge. Am J Respir Cell Mol Biol2001 24 ( ) : 682 ~ 7
/ / Chung HT. Analysis of thepolymorphisms in eotaxin gene family and their associationwith asthma 320 : 131 ~ 7
/ / Chung HT. Molecular variations in Th1-specificcell surface gene Tim-3. Exp Mol Med 2004 30 : 274 ~ 8
/ / Chung HT. The associationof eotaxin-2 and eotaxin-3 gene polymorphisms in aKorean population with allergic rhinitis. Immunogenetics2005 56 : 760 ~ 4
/ / Coffman RL. Regulation of immunity to parasites byT cells and T cell-derived cytokines. Annu Rev Immunol1992 : 385 ~ 409
/ / Chung HT. Analysis of thepolymorphisms in eotaxin gene family and their associationwith asthma 320 : 131 ~ 7
/ / Chung HT. Molecular variations in Th1-specificcell surface gene Tim-3. Exp Mol Med 2004 30 : 274 ~ 8
/ / Chung HT. The associationof eotaxin-2 and eotaxin-3 gene polymorphisms in aKorean population with allergic rhinitis. Immunogenetics2005 56 : 760 ~ 4
/ / Coffman RL. Regulation of immunity to parasites byT cells and T cell-derived cytokines. Annu Rev Immunol1992 : 385 ~ 409
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