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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 575 - 587 (13page)
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초록· 키워드
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Rac1 and Rac2 are essential for the control of oxidative burst catalyzed by NADPH oxidase. It was also documented that Rho is associated with the superoxide burst reaction during phagocytosis of serum- (SOZ) and IgG-opsonized zymosan particles (IOZ). In this study, we attempted to reveal the signal pathway components in the superoxide formation regulated by Rho GTPase. Tat-C3 blocked superoxide production, suggesting that RhoA is essentially involved in superoxide formation during phagocytosis of SOZ. Conversely SOZ activated both RhoA and Rac1/2. Inhibition of RhoA-activated kinase (ROCK), an important downstream effector of RhoA, by Y27632 and myosin light chain kinase (MLCK) by ML-7 abrogated superoxide production by SOZ. Extracellular sig-naling-regulated kinase (ERK)1/2 and p38 mitogen- activated protein kinase (MAPK) were activated during phagocytosis of SOZ, and Tat-C3 and SB203580 reduced ERK1/2 and p38 MAPK activation, suggesting that RhoA and p38 MAPK may be upstream regulators phatidyl inositol 3-kinase did not block translocation of RhoA to membranes, suggesting that RhoA is upstream to these kinases. Inhibition of RhoA by Tat-C3 blocked phosphorylation of p47PHOX. Taken together, RhoA, ROCK, p38MAPK, ERK1/2, and p47PHOX may be subsequently activated, leading to activation of NADPH oxidase to produce superoxide.
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참고문헌 (30)
참고문헌 신청
/ / Activation of p38 in stimulated human neutrophils phosphorylation of the oxidase component p47phox by p38and ERK but not by JNK : 395 ~ 400
/ / Biologically active lipidsare regulators of Rac : 26206 ~ 11
/ / Identification of two distinct mechanisms ofphagocytosis controlled by different Rho GTPases Science1998 : 1717 ~ 21
/ / Naphthalenesulphonamides block neutrophil superoxideproduction by intact cells and in a cell-free system is myosinlight chain kinase responsible for these effects : 81 ~
/ / Regulation of the human neutrophil NADPHoxidase by the Rac GTP-binding proteins : 212 ~ 8
/ / Biologically active lipidsare regulators of Rac : 26206 ~ 11
/ / Identification of two distinct mechanisms ofphagocytosis controlled by different Rho GTPases Science1998 : 1717 ~ 21
/ / Naphthalenesulphonamides block neutrophil superoxideproduction by intact cells and in a cell-free system is myosinlight chain kinase responsible for these effects : 81 ~
/ / Regulation of the human neutrophil NADPHoxidase by the Rac GTP-binding proteins : 212 ~ 8
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