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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 507 - 511 (5page)
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Imatinib mesylate is a selective Bcr/Abl kinase inhibitor and an effective anticancer agent for Bcr/Abl-positive chronic myelogenous leukemia. Most patients in chronic phase maintain durable responses; however, many in blast crisis fail to respond, or relapse quickly. Mutations within the BCR/ABL kinase domain are the most commonly identified mechanism associated with relapse. To overcome the imatinib resistance in CML, many investigators have tried to clarify molecular mecha-nism for imatinib resistance in cells of patients who failed to respond to imatinib. Our aim was to inve-sitigate underlying mechanism for imatinib resi-stance in SR-1 cells, which were derived from a CML patient in blast crisis. We detected the new mutation of BCR/ABL, resulting in premature termination and loss of BCR/ABL fusion protein expression, which might be possible mechanism for the resistance to imatinib in SR-1 cells.
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등록된 정보가 없습니다.
참고문헌 (7)
참고문헌 신청
/ / J rgensenP. Multiplex reverse transcription-polymerase chain reaction forsimultaneous screening of 29 translocations and chromosomalaberrations in acute leukemia. Blood 1
/ / Kim HJ. Establishment and characterization of anSTI571-resistant human myelogenous leukemia cell line : 52 ~ 6
/ / Morre E. Hematologic and cytogenetic responsesto imatinib mesylate in chronic myelogenous leukemia. N EnglJ Med 2002 lazzari (m) : 645 ~ 52
/ / Rapid colorimetric assay for cellular growth andsurvival application to proliferation and cytotoxic assays. JImmunol Methods 1983 65 : 55 ~ 63
/ / Sawyers CL. Clinical resistance to STI-571 cancer therapycaused by BCR-ABL gene mutation or amplification. Science2001 : 876 ~ 80
/ / Kim HJ. Establishment and characterization of anSTI571-resistant human myelogenous leukemia cell line : 52 ~ 6
/ / Morre E. Hematologic and cytogenetic responsesto imatinib mesylate in chronic myelogenous leukemia. N EnglJ Med 2002 lazzari (m) : 645 ~ 52
/ / Rapid colorimetric assay for cellular growth andsurvival application to proliferation and cytotoxic assays. JImmunol Methods 1983 65 : 55 ~ 63
/ / Sawyers CL. Clinical resistance to STI-571 cancer therapycaused by BCR-ABL gene mutation or amplification. Science2001 : 876 ~ 80
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