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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1 - 12 (12page)
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In this review, we explain why and how rabbit monoclonal antibodies have become outstanding reagents for laboratory research and increasingly for diagnostic and therapeutic applications. Starting with the unique ontogeny of rabbit B cells that affords highly distinctive antibody repertoires rich in in vivo pruned binders of high diversity, affinity and specificity, we describe the generation of rabbit monoclonal antibodies by hybridoma technology, phage display and alternative methods, along with an account of successful humanization strategies.
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참고문헌 (26)
참고문헌 신청
Ayyar BV / 2015 / Facile domain rearrangement abrogates expression recalcitrance in a rabbit scFv / Appl Microbiol Biotechnol 99 : 2693 ~ 2703
Berger C / 2015 / Safety of targeting ROR1 in primates with chimeric antigen receptor-modified T cells / Cancer Immunol Res 3 : 206 ~ 216
Borras L / 2010 / Generic approach for the generation of stable humanized singlechain Fv fragments from rabbit monoclonal antibodies / J Biol Chem 285 : 9054 ~ 9066
Campbell K / 2007 / Assessment of specific binding proteins suitable for the detection of paralytic shellfish poisons using optical biosensor technology / Anal Chem 79 : 5906
Chan AC / 2010 / Therapeutic antibodies for autoimmunity and inflammation / Nat Rev Immunol 10 : 301 ~ 316
Berger C / 2015 / Safety of targeting ROR1 in primates with chimeric antigen receptor-modified T cells / Cancer Immunol Res 3 : 206 ~ 216
Borras L / 2010 / Generic approach for the generation of stable humanized singlechain Fv fragments from rabbit monoclonal antibodies / J Biol Chem 285 : 9054 ~ 9066
Campbell K / 2007 / Assessment of specific binding proteins suitable for the detection of paralytic shellfish poisons using optical biosensor technology / Anal Chem 79 : 5906
Chan AC / 2010 / Therapeutic antibodies for autoimmunity and inflammation / Nat Rev Immunol 10 : 301 ~ 316
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