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- 자료유형
- 학술저널
- 저자정보
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- 2015.1
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Gephyrin is a central element that anchors, clusters and stabilizes glycine and γ-aminobutyric acid type A receptors at inhibitory synapses of the mammalian brain. It self-assembles into a hexagonal lattice and interacts with various inhibitory synaptic proteins. Intriguingly, the clustering of gephyrin, which is regulated by multiple posttranslational modifications, is critical for inhibitory synapse formation and function. In this review, we summarize the basic properties of gephyrin and describe recent findings regarding its roles in inhibitory synapse formation, function and plasticity. We will also discuss the implications for the pathophysiology of brain disorders and raise the remaining open questions in this field.
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참고문헌 (26)
참고문헌 신청
Bedet C / 2006 / Regulation of gephyrin assembly and glycine receptor synaptic stability / J Biol Chem 281 : 30046 ~ 30056
Fritschy JM / 2008 / Gephyrin: where do we stand, where do we go? / Trends Neurosci 31 : 257 ~ 264
Herweg J / 2012 / Splice-specific glycine receptor binding, folding, and phosphorylation of the scaffolding protein gephyrin / J Biol Chem 287 : 12645 ~ 12656
Kamdar KP / 1994 / The Drosophila molybdenum cofactor gene cinnamon is homologous to three Escherichia coli cofactor proteins and to the rat protein gephyrin / Genetics 137
Kim EY / 2006 / Deciphering the structural framework of glycine receptor anchoring by gephyrin / EMBO J 25 : 1385 ~ 1395
Fritschy JM / 2008 / Gephyrin: where do we stand, where do we go? / Trends Neurosci 31 : 257 ~ 264
Herweg J / 2012 / Splice-specific glycine receptor binding, folding, and phosphorylation of the scaffolding protein gephyrin / J Biol Chem 287 : 12645 ~ 12656
Kamdar KP / 1994 / The Drosophila molybdenum cofactor gene cinnamon is homologous to three Escherichia coli cofactor proteins and to the rat protein gephyrin / Genetics 137
Kim EY / 2006 / Deciphering the structural framework of glycine receptor anchoring by gephyrin / EMBO J 25 : 1385 ~ 1395
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