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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 189 - 200 (12page)
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Protein phosphatase-1 (PP1) nuclear targeting subunit
(PNUTS), also called PP1R10, p99, or CAT 53 was
originally isolated as a mammalian nuclear PP1-binding
protein. In this study, we performed yeast two-hybrid
screens to identify PNUTS-interacting proteins.
Here, we report that LCP1 (epidermal Langerhans cell
protein 1), a novel member of the HMG-box protein family,
binds tightly to PNUTS. Co-immunoprecipitation of
deletion constructs revealed that the C-terminus of
LCP1 is sufficient for the interaction with an N-terminal
region of PNUTS that is distinct from its PP1-binding
domain. Furthermore, immunofluorescence studies
showed that a subpopulation of LCP1 co-localizes with
PNUTS in nuclear speckles. Importantly, we found that
the N-terminus of LCP1 has a strong trans-activation
activity in a GAL4-based heterologous transcription
assay. The transcriptional activity of LCP1 is markedly
suppressed by its interaction with PNUTS, in a PP1-independent
manner. These findings suggest that the
coordinated spatial and temporal regulation of LCP1
and PNUTS may be a novel mechanism to control the
expression of genes that are critical for certain physiological
and pathological processes.
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참고문헌 (24)
참고문헌 신청
Aidinis V / 1999 / The RAG1 homeodomain recruits HMG1 and HMG2 to facilitate recombination signal sequence binding and to enhance the intrinsic DNA-bending activity of RAG1-R
Aliahmad P / 2008 / Development of all CD4 T lineages requires nuclear factor TOX / J Exp Med 205 : 245 ~ 256
Allen PB / 1998 / Isolation and characterization of PNUTS, a putative protein phosphatase 1 nuclear targeting subunit / J Biol Chem 273 : 4089 ~ 4095
Baxevanis AD / 1995 / The HMG-1 box protein family:classification and functional relationships / Nucleic Acids Res 23 : 1604 ~ 1613
Bewley CA / 1998 / Minor groovebinding architectural proteins: structure, function, and DNA recognition / Annu Rev Biophys Biomol Struct 27 : 105 ~ 131
Aliahmad P / 2008 / Development of all CD4 T lineages requires nuclear factor TOX / J Exp Med 205 : 245 ~ 256
Allen PB / 1998 / Isolation and characterization of PNUTS, a putative protein phosphatase 1 nuclear targeting subunit / J Biol Chem 273 : 4089 ~ 4095
Baxevanis AD / 1995 / The HMG-1 box protein family:classification and functional relationships / Nucleic Acids Res 23 : 1604 ~ 1613
Bewley CA / 1998 / Minor groovebinding architectural proteins: structure, function, and DNA recognition / Annu Rev Biophys Biomol Struct 27 : 105 ~ 131
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