지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
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- 1 - 7 (7page)
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Aging-dependent cellular behaviors toward extrinsic stress are characterized by the confined localization of certain molecules to either nuclear or perinuclear regions. Although most growth factors can activate downstream signaling in aging cells, they do not in fact have any impact on the cells because the signals cannot reach their genetic targets in the nucleus. For the same reason, varying apoptotic stress factors cannot stimulate the apoptotic pathway in senescent cells. Thus, the operation of a functional nuclear barrier in an aging-dependent manner has been investigated. To elucidate the mechanism for this process, the housekeeping transcription factor Sp1 was identified as a general regulator of nucleocytoplasmic trafficking (NCT) genes, including various nucleoporins, importins, exportins and Ran GTPase cycle-related genes. Interestingly, the posttranslational modification of Sp1 is readily influenced by extrinsic stress, including oxidative and metabolic stress. The decrease in SP1 O-GlcNAcylation under oxidative stress or during replicative senescence makes it susceptible to proteosomal degradation, resulting in defective NCT functions and leading to nuclear barrier formation. The operation of the nuclear barrier in aging provides a fundamental mechanism for cellular protection against stress and promotes survival at the expense of growth via stress-sensitive transcriptional control.
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참고문헌 (22)
참고문헌 신청
Anderson RG / 1998 / The caveolae membrane system / Annu Rev Biochem 67 : 199 ~ 225
Bretscher MS / 1977 / Membrane-Associated Vesicles in Fibroblasts / J Ultra Mol Struct R 61 : 215 ~ 217
Carlin CR / 1983 / Diminished in vitro tyrosine kinase activity of the EGF receptor of senescent human fibroblasts / Nature 306 : 617 ~ 620
Chapman HA / 1999 / Role of urokinase receptor and caveolin in regulation of integrin signaling / Thromb Haemost 82 : 291 ~ 29
Cho KA / 2005 / Caveolin-1 as a prime modulator of aging: a new modality for phenotypic restoration? / Mech Ageing Dev 126 : 105 ~ 110
Bretscher MS / 1977 / Membrane-Associated Vesicles in Fibroblasts / J Ultra Mol Struct R 61 : 215 ~ 217
Carlin CR / 1983 / Diminished in vitro tyrosine kinase activity of the EGF receptor of senescent human fibroblasts / Nature 306 : 617 ~ 620
Chapman HA / 1999 / Role of urokinase receptor and caveolin in regulation of integrin signaling / Thromb Haemost 82 : 291 ~ 29
Cho KA / 2005 / Caveolin-1 as a prime modulator of aging: a new modality for phenotypic restoration? / Mech Ageing Dev 126 : 105 ~ 110
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