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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 471 - 477 (7page)
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초록· 키워드
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Down syndrome critical region 1 (DSCR1), an oxidative
stress-response gene, interacts with calcineurin and
represses its phosphatase activity. Recently it was
shown that hydrogen peroxide inactivates calcineurin
by proteolytic cleavage. Based on these facts, we investigated
whether oxidative stress affects DSCR1-
mediated inactivation of calcineurin. We determined
that overexpression of DSCR1 leads to increased proteolytic
cleavage of calcineurin. Convertsely, knockdown
of DSCR1 abolished calcineurin cleavage upon
treatment with hydrogen peroxide. The PXIIXT motif in
the COOH-terminus of DSCR1 is responsible for both
binding and cleavage of calcineurin. The knockdown
of overexpressed DSCR1 in DS fibroblast cells also abrogated
calcineurin proteolysis by hydrogen peroxide.
These results suggest that DSCR1 has the ability to inactivate
calcineurin by inducing proteolytic cleavage
of calcineurin upon oxidative stress.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Aramburu J / 2000 / Calcineurin: from structure to function / Curr. Top. Cell. Regul 36 : 237 ~ 295
Aubareda A / 2006 / Functional characterization of the calcipressin 1 motif that suppresses calcineurin-mediated NFAT-dependent cytokine gene expression in human T cells / Ce
Bu-Yeon Kim / 2008 / Nur77 upregulates HIF-α by inhibiting pVHL-mediateddegradation / Experimental and Molecular Medicine 40 (1) : 71 ~ 83
Chan B / 2005 / Identification of a peptide fragment of DSCR1 that competitively inhibits calcineurin activity in vitro and in vivo / Proc Natl Acad Sci USA 102 : 13075 ~ 130
Crabtree GR / 2001 / Calcium, calcineurin, and the control of transcription / J. Biol. Chem 276 : 2313 ~ 2316
Aubareda A / 2006 / Functional characterization of the calcipressin 1 motif that suppresses calcineurin-mediated NFAT-dependent cytokine gene expression in human T cells / Ce
Bu-Yeon Kim / 2008 / Nur77 upregulates HIF-α by inhibiting pVHL-mediateddegradation / Experimental and Molecular Medicine 40 (1) : 71 ~ 83
Chan B / 2005 / Identification of a peptide fragment of DSCR1 that competitively inhibits calcineurin activity in vitro and in vivo / Proc Natl Acad Sci USA 102 : 13075 ~ 130
Crabtree GR / 2001 / Calcium, calcineurin, and the control of transcription / J. Biol. Chem 276 : 2313 ~ 2316
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