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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 371 - 380 (10page)
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초록· 키워드
오류제보하기
During carcinogenesis, NF-κB mediates processes associated
with deregulation of the normal control of proliferation,
angiogenesis, and metastasis. Thus, suppression
of NF-κB has been linked with chemoprevention
of cancer. Accumulating findings reveal
that heat shock protein 90 (HSP90) is a molecular chaperone
and a component of the IκB kinase (IKK) complex
that plays a central role in NF-κB activation. HSP90 also
stabilizes key proteins involved in cell cycle control
and apoptosis signaling. We have determined whether
the exogenous administration of isoflavone-deprived
soy peptide prevents 7,12-dimethylbenz[α]anthracene
(DMBA)-induced rat mammary tumorigenesis and
investigated the mechanism of action. Dietary administration
of soy peptide (3.3 g/rat/day) significantly reduced
the incidence of ductal carcinomas (50%), the
number of tumors per multiple tumor-bearing rats
(49% P ＜ 0.05), and extended the latency period of tumor
development (8.07 ± 0.92 weeks) compared to
control diet animals (10.80 ± 1.30 P ＜ 0.05). Our results
have further demonstrated that soy peptide (1)
dramatically inhibits the expression of HSP90, thereby
suppressing signaling pathway leading to NF-κB activation;
(2) induces expression of p21, p53, and caspase-
3 proteins; and (3) inhibits expression of VEGF.
In agreement with our in vivo data, soy peptide treatment
inhibited the growth of human breast MCF-7 tumor
cells in a dose-dependent manner and induced
apoptosis. Taken together, our in vivo and in vitro results
suggest chemopreventive and tumor suppressive
functions of isoflavone-deprived soy peptide
by inducing growth arrest and apoptosis.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Banerjee S / 1996 / Multi-targeted therapy of cancer by genistein. Cancer Lett 2008;269:226-42 Beg AA, Baltimore D. An essential role for NF-kappaB in preventing TNF-alpha-in
Banerjee S / 2002 / Suppression of 7,12-dimethylbenz(a) anthracene - induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappa B, cyclooxygenase 2,
Bharti AC / 2002 / Nuclear factor-kappa B and cancer: its role in prevention and therapy / Biochem Pharmacol 64 : 883 ~ 888
Broemer M / 2004 / Requirement of Hsp90 activity for Ikappa B kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-kappaB activation / Oncogene 23 : 5378 ~
Chen G / 2002 / TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90 / Mol Cell 9 : 401 ~ 410
Banerjee S / 2002 / Suppression of 7,12-dimethylbenz(a) anthracene - induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappa B, cyclooxygenase 2,
Bharti AC / 2002 / Nuclear factor-kappa B and cancer: its role in prevention and therapy / Biochem Pharmacol 64 : 883 ~ 888
Broemer M / 2004 / Requirement of Hsp90 activity for Ikappa B kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-kappaB activation / Oncogene 23 : 5378 ~
Chen G / 2002 / TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90 / Mol Cell 9 : 401 ~ 410
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