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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 440 - 452 (13page)
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초록· 키워드
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When we treated rat bone marrow stromal cells
(rBMSCs) with neuronal differentiation induction media,
typical unfolded protein response (UPR) was
observed. BIP/GRP78 protein expression was time-dependently
increased, and three branches of UPR were
all activated. ATF6 increased the transcription of XBP1
which was successfully spliced by IRE1. PERK was
phosphorylated and it was followed by eIF2α
phosphorylation. Transcription of two downstream
targets of eIF2α, ATF4 and CHOP/GADD153, were transiently
up-regulated with the peak level at 24 h.
Immunocytochemical study showed clear coexpression
of BIP and ATF4 with NeuN and Map2,
respectively. UPR was also observed during the neuronal
differentiation of mouse embryonic stem (mES)
cells. Finally, chemical endoplasmic reticulum (ER)
stress inducers, thapsigargin, tunicamycin, and brefeldin
A, dose-dependently increased both mRNA and
protein expressions of NF-L, and, its expression was
specific to BIP-positive rBMSCs. Our results showing
the induction of UPR during neuronal differentiations
of rBMSCs and mES cells as well as NF-L expression
by ER stress inducers strongly suggest the potential
role of UPR in neuronal differentiation.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Alvarez-Dolado M / 2003 / Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes / Nature 425 : 968 ~ 973
Chan K / 1996 / NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development / Proc Natl Acad Sci USA 93 :
Choi CB / 2006 / Analysis of neuron-like differentiation of human bone marrow mesenchymal stem cells / Biochem Biophys Res Commun 350 : 138 ~ 146
Chung S / 2005 / The homeodomain transcription factor Pitx3 facilitates differentiation of mouse embryonic stem cells into AHD2-expressing dopaminergic neurons / Mol Cell Neu
Cogle CR / 2004 / Bone marrow transdifferentiation in brain after transplantation: a retrospective study / Lancet 363 : 1432 ~ 1437
Chan K / 1996 / NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development / Proc Natl Acad Sci USA 93 :
Choi CB / 2006 / Analysis of neuron-like differentiation of human bone marrow mesenchymal stem cells / Biochem Biophys Res Commun 350 : 138 ~ 146
Chung S / 2005 / The homeodomain transcription factor Pitx3 facilitates differentiation of mouse embryonic stem cells into AHD2-expressing dopaminergic neurons / Mol Cell Neu
Cogle CR / 2004 / Bone marrow transdifferentiation in brain after transplantation: a retrospective study / Lancet 363 : 1432 ~ 1437
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