지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 406 - 416 (11page)
이용수
초록· 키워드
오류제보하기
Peroxisome proliferator activated receptor (PPAR) γ
coactivator-1α (PGC-1α) may be implicated in cholesterol
metabolism since PGC-1α co-activates estrogen
receptor α (ERα) transactivity and estrogen/ERα induces
the transcription of LDL receptor (LDLR). Here,
we show that overexpression of PGC-1α in HepG2 cells
represses the gene expression of LDLR and does not
affect the ERα-induced LDLR expression. PGC-1α
suppressed the LDLR promoter-luciferase (pLR1563-
luc) activity regardless of cholesterol or functional
sterol-regulatory element-1. Serial deletions of the
LDLR promoter revealed that the inhibition by PGC-1α
required the LDLR promoter regions between -650 bp
and -974 bp. Phosphorylation of PGC-1α may not affect
the suppression of LDLR expression because treatment
of SB202190, a p38 MAP kinase inhibitor, did not
reverse the LDLR down-regulation by PGC-1α. This
may be the first report showing the repressive function
of PGC-1α on gene expression. PGC-1α might be a novel
modulator of LDLR gene expression in a sterol-independent
manner, and implicated in atherogenesis.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Barbera MJ / 2001 / Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the ther
Bennett MK / 1999 / Co-stimulation of promoter for low density lipoprotein receptor gene by sterol regulatory element- binding protein and Sp1 is specifically disrupted by th
Bruning JC / 2003 / Estrogen receptor-alpha and Sp1 interact in the induction of the low density lipoproteinreceptor / J Steroid Biochem Mol Biol 86 : 113 ~ 121
Choi YS / 2006 / Impaired coactivator activity of the Gly482 variant of peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) on mitochondrial tran
Cooper AD / 1987 / Characterization of the estrogen-induced lipoprotein receptor of rat liver / J Lipid Res 28 : 59 ~ 68
Bennett MK / 1999 / Co-stimulation of promoter for low density lipoprotein receptor gene by sterol regulatory element- binding protein and Sp1 is specifically disrupted by th
Bruning JC / 2003 / Estrogen receptor-alpha and Sp1 interact in the induction of the low density lipoproteinreceptor / J Steroid Biochem Mol Biol 86 : 113 ~ 121
Choi YS / 2006 / Impaired coactivator activity of the Gly482 variant of peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) on mitochondrial tran
Cooper AD / 1987 / Characterization of the estrogen-induced lipoprotein receptor of rat liver / J Lipid Res 28 : 59 ~ 68
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Circadian regulation of low density lipoprotein receptor promoter activity by CLOCK/BMAL1, Hes1 and Hes6
Experimental and Molecular Medicine
2012 .01
-
Opuntia humifusa Supplementation Reduces Fat Weight by Increasing PPAR-γ and PGC-1α Protein Expression in the Skeletal Muscle of Rats
생명과학회지
2014 .01
-
Effect of Salicornia herbacea L. Supplementation on Tissue Triglyceride Concentrations and PGC-1α & PPAR-γ Expression of Skeletal Muscle of Rats Fed a High-fat Diet
생명과학회지
2018 .07
-
Inhibitory effects of tilianin on the expression of inducible nitric oxide synthase in low density lipoprotein receptor deficiency mice
Experimental and Molecular Medicine
2006 .01
-
Potassium Gold Cyanide(PGC) 중 Au 시험방법 개발
한국분석과학회 학술대회
2013 .11
-
규칙적 운동이 고지방식이 난소절제흰쥐의 지방세포에서 미토콘드리아 생합성 유전자들의 변화
생명과학회지
2011 .07
-
Peroxisome proliferator-activated receptor δ agonist attenuates hepatic steatosis by anti-inflammatory mechanism
Experimental and Molecular Medicine
2012 .01
-
Determination of NDELA in cosmetic ingredients and products by mixed mode SPE and UPLC-MS/MS with PGC column
한국분석과학회 학술대회
2013 .11
-
Constitutive Androstane Receptor (CAR)의 활성, 에너지 대사 및 세포의 증식과 사멸의 조절에 대한 CAR의 cross-talk 기전
생명과학회지
2020 .02
-
Analysis of Hot Pepper Promoters and Gene Expression Regulation
한국유전체학회 Conference
2003 .01
-
NcoI Restriction Fragment Length Polymorphism of the Tumor Necrosis Factor (TNF$\alpha$) Promoter in Korean
한국동물학회 학술대회
1995 .01
-
Promoter effects of adeno-associated viral vector for transgeneexpression in the cochlea in vivo
Experimental and Molecular Medicine
2007 .01
-
Screening of Promoters from Metagenomic DNA and Their Use for the Construction of Expression Vectors
Journal of Microbiology and Biotechnology
2008 .01
-
Building the Frequency Profile of the Core Promoter Element Patterns in the Three ChromHMM Promoter States at 200bp Intervals: A Statistical Perspective
Genomics & informatics
2015 .01
-
Receptor Modeling
한국대기환경학회 학술대회논문집
1994 .01
-
유방암 세포와 간암세포에 있어서 에스트로겐 수용체의 전사조절기능에 대한 Xenobiotic 핵 수용체 (Constitutive Androstane Receptor, Steroid and Xenobiotic Receptor, Peroxisome-Proliferator-Activated Receptorγ)의 영향 비교분석
생명과학회지
2003 .06
-
Promoter Structure and Transcriptional Activity of Human Complement Receptor Type I (CR1) Gene
Korean journal of biological sciences
2003 .01
-
Characterization of the Promoter Controling the Stage-Specific Gene Expression of Bombyx mori
생명과학회지
2011 .10
-
Structural Characteristics of Two Wheat Histone H2A Genes Encoding Distinct Types of Variants and Functional Differences in Their Promoter Activity
한국식물학회 심포지움
1996 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0