지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 445 - 452 (8page)
이용수
초록· 키워드
오류제보하기
We investigated the effect of tilianin upon inducible nitric oxide synthesis in the plasma of low-density lipoprotein receptor knock-out (Ldlr-/-) mice fed with high cholesterol diet and in primary peritoneal macrophages of Ldlr-/- mice. High cholesterol diet induced nitric oxide production in the plasma of Ldlr-/- mice. Tilianin reduced the level of nitric oxide (NO) in plasma from Ldlr-/- mice induced by the high cholesterol diet. Tilianin also inhibited the NO production from the primary culture of peritoneal macrophages treated with lipopolysaccharide. The inhibition of NO production was caused by the suppression of inducible nitric oxide synthase (iNOS) gene expression in peritoneal macrophages isolated from Ldlr-/- mice. Moreover, tilianin inhibited the transcriptional activation of iNOS promoter that has NF-κB binding element. Thus, these results provide the first evidence that tilianin inhibit iNOS expression and production of NO and may act as a potential anti-inflammatory agent.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
[학술지(정기간행물)
/ 1987 / Quantitative assessment of atherosclerotic lesions in mice 68 : 231 ~ 40
/ 1988 / Nitric oxide: a cytotoxic activated macrophage effector molecule 57 : 87 ~ 94
/ 1990 / Apparent hydroxyl radical production by peroxynitrite: im-plications for endothelial injury from nitric oxide and superoxide 87 : 1620 ~ 4
/ 1991 / Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-indepen-dent and inhibited by ar
/ 1987 / Quantitative assessment of atherosclerotic lesions in mice 68 : 231 ~ 40
/ 1988 / Nitric oxide: a cytotoxic activated macrophage effector molecule 57 : 87 ~ 94
/ 1990 / Apparent hydroxyl radical production by peroxynitrite: im-plications for endothelial injury from nitric oxide and superoxide 87 : 1620 ~ 4
/ 1991 / Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-indepen-dent and inhibited by ar
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Effects of Acute Exercise on Nitric Oxide Generation from Mouse Macrophages
Nutritional Sciences
2002 .08
-
Circadian regulation of low density lipoprotein receptor promoter activity by CLOCK/BMAL1, Hes1 and Hes6
Experimental and Molecular Medicine
2012 .01
-
Tilianin Inhibits MUC5AC Expression Mediated Via Down-Regulation of EGFR-MEK-ERK-Sp1 Signaling Pathway in NCI-H292 Human Airway Cells
Journal of Microbiology and Biotechnology
2017 .01
-
Sterol-independent repression of low density lipoprotein receptor promoter by peroxisome proliferator activated receptor γ coactivator-1α (PGC-1α)
Experimental and Molecular Medicine
2009 .01
-
백삼성분이 마우스 복강 탐식세포의 증식 및 Nitric Oxide 생성에 미치는 영향 ( Effect of White Ginseng on the Proliferation of Mouse Peritoneal Macrophages and Their Nitric Oxide Synthesis )
동아시아식생활학회지
1997 .12
-
Nitric Oxide and Tumor Necrosis Factor-alpha Production by Arctium lappa in Mouse Peritoneal Macrophages
한국동물학회 학술대회
2003 .01
-
Nitric oxide suppresses inducible nitric oxide synthase expression by inhibiting post- translational modification of IκB
Experimental and Molecular Medicine
2004 .01
-
Induction of hepatic inducible nitric oxide synthase by cholesterol in vivo and in vitro
Experimental and Molecular Medicine
2002 .01
-
Lipoprotein is a Major Cell Wall Component of Staphylococcus aureus to Induce Nitric Oxide Production in Macrophages
한국미생물학회 학술대회논문집
2015 .04
-
Immuno- and Enzyme-Histochemical Studies on the n-Nitric Oxide Synthase in the Mouse Renal Cortex after High-Salt Diet
한국동물학회 학술대회
1998 .01
-
Production of Nitric Oxide under Ultraviolet-B Irradiation is Mediated by Hydrogen Peroxide through Activation of Nitric Oxide Synthase
식물학회지
2008 .01
-
Induction of nitric oxide synthase (NOS) by soluble glucocorticoid induced tumor necrosis factor receptor (sGITR) is modulated by IFN-γ in murine macrophage
Experimental and Molecular Medicine
2003 .01
-
Signal Transduction of AMPs on Cold Adapted Mouse Peritoneal Macrophage
한국동물학회 학술대회
1997 .01
-
β-Carotene inhibits inflammatory gene expression in lipopolysaccharide-stimulatedmacrophages by suppressing redox-based NF-κB activation
Experimental and Molecular Medicine
2005 .01
-
Candida spp.- Induced Cytokine Gene Expression on Mouse Peritoneal Macrophages and NIH 3T3 Fibroblasts
The Journal of the Korean Society for Microbiology
1998 .06
-
NO ( nitric oxide ) 를 이용한 SO2의 촉매 산화반응 연구 ( A Study on the Catalytic Oxidation of SO2 using NO ( nitric oxide ) )
한국대기환경학회 학술대회논문집
1996 .01
-
Differential regulation of inducible nitric oxide synthase and cyclooxygenase-2 expression by superoxide dismutase in lipopolysaccharide stimulated RAW 264.7 cells
Experimental and Molecular Medicine
2009 .01
-
Analysis of Nitric Oxide Production and Its Role during Fungal Differentiation
한국미생물학회 학술대회논문집
2017 .04
-
Soluble factor from tumor cells induces heme oxygenase-1 by a nitric oxide-independent mechanism in murine peritoneal macrophages
Experimental and Molecular Medicine
2003 .01
-
Induction of Nitric Oxide Synthase in Monocyte and Macrophage Cell Lilies by Cell Adhesion
한국동물학회 학술대회
1997 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0