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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 243 - 250 (8page)
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초록· 키워드
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Insulin-like growth factor (IGF)/IGF binding pro-tein (IGFBP) abnormalities may be important in the pathogenesis of growth failure in chronic renal failure (CRF). We induced experimental CRF by 5/6 nephrectomy in Sprague Dawley rats (10 g) and observed for 2 weks comparing with CRF rats gained 30% less height than Sham- C rats (P＜ 0.01). Serum IGFBP profiles by Western ligand blot revealed that IGFBP4 was elevated two fold in CRF rats (P ＜ 0.01 vs. Sham-C). However, IGFBP4 mRNA levels in liver or skeletal muscle were not diferent in two groups. To determine if the increase of serum IGFBP4 in CRF retarded the growth of cartilage, epiphyseal chondrocytes were isolated from CRF or control rats and cultured in the presence of serum reduced proliferations of normal chondrocytes and L6 rat skeletal muscle cels. In contrast, 10% CRF serum did not inhibit the growth of CRF chondrocytes. Rat sera from two groups were separated into two diferent frac-tions, high (＞10 kDa, containing IGFBPs) and low (＜10 kDa, containing fre IGF) molecular weight fractions using a gel filtration column. Both fractions obtained from CRF sera de-creased the growth of control chondrocytes up We suggest that the pathogenesis of growth failure in CRF may be involved in the increase of circulating IGFBP4 as wel as the unidentified small molecular weight uremic serum factors which block the growth of chondrocytes in growth plate.
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참고문헌 (22)
참고문헌 신청
/ / -independent action of IGF-binding pro-tein-3 in Hs578T human breast cancer cells : 14964 ~ 71
/ / Analysis of serum insulin-like growth factor binding proteins using western blotting use of the method for titration of the binding proteins and competitive binding studi
/ / Demonstration of receptors for insulin-like growth factor binding protein-3 on Hs578T human breast cancer cells : 26045 ~ 8
/ / Disturbance of growthhormone-insulin-like growth factor axis in uraemia Impli-cations for recombinant human growth hormone treatment Pediatr Nephrol 1990 : 654 ~ 62
/ / Insulin-like growth factor-binding protein from human plasma Purification and characterization J Biol Chem 1986 : 8754 ~ 60
/ / Analysis of serum insulin-like growth factor binding proteins using western blotting use of the method for titration of the binding proteins and competitive binding studi
/ / Demonstration of receptors for insulin-like growth factor binding protein-3 on Hs578T human breast cancer cells : 26045 ~ 8
/ / Disturbance of growthhormone-insulin-like growth factor axis in uraemia Impli-cations for recombinant human growth hormone treatment Pediatr Nephrol 1990 : 654 ~ 62
/ / Insulin-like growth factor-binding protein from human plasma Purification and characterization J Biol Chem 1986 : 8754 ~ 60
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