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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 728 - 736 (9page)
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초록· 키워드
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The adaptor protein, LAD/TSAd, plays essential roles in T cell activation. To further understand the functions of this protein, we performed yeast two-hybrid screening using TSAd as bait and identified 67 kDa laminin binding protein (LBP) as the interacting partner.
Subsequently, TSAd-LBP interaction was confirmed in D1.1 T cell line. Upon costimulation by T cell receptor (TCR) plus laminin crosslinking or TCR plus integrin α6 crosslinking, LBP was coimmunoprecipitated with TSAd. Moreover, TCR plus laminin costimulation-dependent T cell migration was enhanced in D1.1 T cells overexpressing TSAd but was disrupted in D1.1 cells overexpressing dominant negative form of TSAd or TSAd shRNA. These data show that, upon TCR plus integrin costimulation, TSAd associates with LBP and mediates T lymphocyte migration.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Ardini E / 1997 / Co-regulation and physical association of the 67-kDa monomeric laminin receptor and the alpha6beta4 integrin / J Biol Chem 272 : 2342 ~ 2345
Belkin AM / 2000 / Integrins as receptors for laminins / Microsc Res Tech 51 : 280 ~ 301
Brummelkamp TR / 2002 / A system for stable expression of short interfering RNAs in mammalian cells / Science 296 : 550 ~ 553
Buto S / 1998 / Formation of the 67-kDa laminin receptor by acylation of the precursor / J Cell Biochem 69 : 244 ~ 251
Canfield SM / 1999 / The nonintegrin laminin binding protein (p67 LBP) is expressed on a subset of activated human T lymphocytes and, together with the integrin very late act
Belkin AM / 2000 / Integrins as receptors for laminins / Microsc Res Tech 51 : 280 ~ 301
Brummelkamp TR / 2002 / A system for stable expression of short interfering RNAs in mammalian cells / Science 296 : 550 ~ 553
Buto S / 1998 / Formation of the 67-kDa laminin receptor by acylation of the precursor / J Cell Biochem 69 : 244 ~ 251
Canfield SM / 1999 / The nonintegrin laminin binding protein (p67 LBP) is expressed on a subset of activated human T lymphocytes and, together with the integrin very late act
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