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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 737 - 745 (9page)
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초록· 키워드
오류제보하기
Paclitaxel is one of the chemotheraputic drugs widely
used for the treatment of nonsmall cell lung cancer
(NSCLC) patients. Here, we tested the ability of
α-tocopheryl succinate (TOS), another promising anticancer
agent, to enhance the paclitaxel response in
NSCLC cells. We found that sub-apoptotic doses of
TOS greatly enhanced paclitaxel-induced growth suppression
and apoptosis in the human H460 NSCLC cell
lines. Our data revealed that this was accounted for primarily
by an augmented cleavage of poly(ADP-ribose)
polymerase (PARP) and enhanced activation of caspase-
8. Pretreatment with z-VAD-FMK (a pan-caspase
inhibitor) or z-IETD-FMK (a caspase-8 inhibitor)
blocked TOS/paclitaxel cotreatment-induced PARP
cleavage and apoptosis, suggesting that TOS potentiates
the paclitaxel-induced apoptosis through enforced
caspase 8 activation in H460 cells. Furthermore,
the growth suppression effect of TOS/paclitaxel combination
on human H460, A549 and H358 NSCLC cell
lines were synergistic. Our observations indicate that
combination of paclitaxel and TOS may offer a novel
therapeutic strategy for improving paclitaxel drug efficacy
in NSCLC patient therapy as well as for potentially
lowering the toxic side effects of paclitaxel through reduced
drug dosage.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Alexandre J / 2006 / Accumulation of hydrogen peroxide is an early and crucial step for TAX-induced cancer cell death both in vitro and in vivo / Int J Cancer 119 : 41 ~ 48
Chou TC / 1984 / Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors / Adv Enzyme Regul 22 : 27 ~ 55
Dong LF / 2008 / α-tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II / Oncogene 27 : 4324 ~ 4335
Dong LF / 2009 / Suppression of tumor growth in vivo by the mitocan α-tocopheryl succinate requires respiratory complex II / Clin Cancer Res 15 : 1593 ~ 1600
Ferreira CG / 2000 / Chemotherapy triggers apoptosis in a caspase-8-dependent and mitochondria-controlled manner in the non-small cell lung cancer cell line NCI-H460 / Cancer
Chou TC / 1984 / Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors / Adv Enzyme Regul 22 : 27 ~ 55
Dong LF / 2008 / α-tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II / Oncogene 27 : 4324 ~ 4335
Dong LF / 2009 / Suppression of tumor growth in vivo by the mitocan α-tocopheryl succinate requires respiratory complex II / Clin Cancer Res 15 : 1593 ~ 1600
Ferreira CG / 2000 / Chemotherapy triggers apoptosis in a caspase-8-dependent and mitochondria-controlled manner in the non-small cell lung cancer cell line NCI-H460 / Cancer
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