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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 398 - 406 (9page)
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Advanced glycation endproducts (AGEs) have been reported to play a role in neointimal formation and increase the rate of in-stent restenosis (ISR) in the diabetic coronary artery disease patients treated with stents, but the potential pathogenic mechanisms of AGEs in vascular smooth muscle cell proliferation remain unclear. We sought to determine the AGEs related pathobiological mechanism of diabetic vasculopathy.
Rat aortic smooth muscle cell (RAoSMC) culture was done with different concentrations of AGEs and proliferation was assessed. Immunohistochemistry for receptor of AGEs (RAGE) was performed with human carotid atheroma. Western blotting was performed to assess the activation of MAP kinase system in the cultured RAoSMC. AGEs increased RAoSMC proliferaproliferation and were associated with increased phosphorylation of ERK and p38 kinase by time and dose dependent manner. The MAP kinase activity was decreased by RNA interference for RAGE. AGEs stimulation increased reactive oxygen species (ROS) generation in cultured RAoSMC. From this study it is concluded that AGEs played a key role in RAoSMC proliferation via MAP kinase dependent pathways.
Activation of vascular smooth muscle cell (VSMC) proliferation by MAP kinase system and increased formation of ROS may be the possible mechanisms of AGEs induced diabetic vasculopathy.
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참고문헌 (21)
참고문헌 신청
Bierhaus A / 1997 / Advanced glycation endproduct-induced activation of NF-κB is suppressed by alpha-lipoic acid in cultured endothelial cells / Diabetes 46 : 1481 ~ 90
Brett J / 1993 / Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues / Am J Pathol 143 : 1699 ~ 712
Brownlee M / 1988 / AGEs in tissue and the biochemical basis of diabetic complications / N Engl J Med 318 : 1315 ~ 21
Brownlee M / 1995 / Advanced glycosylation in diabetes and aging / Ann Rev Med 46 : 223 ~ 34
Chappey O / 1997 / Advanced glycation end products, oxidant stress and vascular lesions / Eur J Clin Invest 27 : 97 ~ 108
Brett J / 1993 / Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues / Am J Pathol 143 : 1699 ~ 712
Brownlee M / 1988 / AGEs in tissue and the biochemical basis of diabetic complications / N Engl J Med 318 : 1315 ~ 21
Brownlee M / 1995 / Advanced glycosylation in diabetes and aging / Ann Rev Med 46 : 223 ~ 34
Chappey O / 1997 / Advanced glycation end products, oxidant stress and vascular lesions / Eur J Clin Invest 27 : 97 ~ 108
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