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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 165 - 171 (7page)
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The p16/INK4A is one of the major target genes in carcinogenesis and its inactivation has fre-quently been reported in other types of tumors. The purpose of this study is to evaluate in-activation paterns of p16/INK4A in oral squamous SC-4, SC-9, SC-15, SC-25, KB, and SNUDH- 379 were examined for inactivation of p16/INK4A genes. In the analysis of p16/INK4A gene inactiva-tion, PCR amplification, direct sequencing, and methylation-specific PCR methods were adopted for evaluation of homozygous deletion, point mu-tation, and promoter hypermethylation, respective-ly. Homozygous deletion was detected in SC-25 and SC-9. SC-15 showed hypermethylated pro-moter region within p16/INK4A gene. It is suges-of p16/INK4A were mainly homozygous deletion, promoter methylation rather than point mutation in oral squamous cancer cell lines, so treatment mo-dalities of oral squamous cell carcinoma should be focused on these types of inactivation.
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참고문헌 (26)
참고문헌 신청
/ / Higher frequency of alterations in the p16/CDKN2 gene insquamous cell carcinoma cell lines than in primary tumorsof the head and neck (bori t) : 5050 ~ 3
/ / Homozygousand hemizygous deletions of 9p centromeric to the interferongenes in lung cancer : 2307 ~ 9
/ / Propagation in a fluid medium of a humanepidermoid carcinoma : 362 ~ 4
/ 1993-8 / Preferential loss of expression of p16
/ 1995 / CDKN2 gene silencing in lung cancer by DNA hypermethylationand kinetics of p16INK4A protein induction by 5-aza2' deoxycitidine : 1211 ~ 6
/ / Homozygousand hemizygous deletions of 9p centromeric to the interferongenes in lung cancer : 2307 ~ 9
/ / Propagation in a fluid medium of a humanepidermoid carcinoma : 362 ~ 4
/ 1993-8 / Preferential loss of expression of p16
/ 1995 / CDKN2 gene silencing in lung cancer by DNA hypermethylationand kinetics of p16INK4A protein induction by 5-aza2' deoxycitidine : 1211 ~ 6
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