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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
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- 1 - 6 (6page)
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Toluene diisocyanate (TDI) exposure can directly activate and damage airway epithelium. Folliculin (FLCN) is a protein expressed by human airway epithelial cells (HAECs) to maintain airway epithelial integrity and survival. This study investigated the involvement of FLCN in the pathogenesis of TDI-induced occupational asthma (OA). Enzyme-linked immunosorbent assay was used to measure serum levels of FLCN in TDI-exposed subjects (93 TDI-OA patients and 119 asymptomatic exposed controls (AEC)), 200 non-occupational asthma (NOA) patients and 71 unexposed healthy normal controls (NCs). Significantly more subjects in the TDI-OA and AEC groups had high serum levels of FLCN compared to those in the NOA group (P=0.002 and P=0.001, respectively), all of which were higher than the NC group (all Po0.001). The serum level of FLCN was positively correlated with TDI exposure duration (r=0.251, P=0.027), but was negatively correlated with asthma duration of TDI-OA patients (r=− 0.329, P=0.029). TDI-exposed subjects with high FLCN levels had higher serum levels of total IgE than those with lower levels. The effects of TDI exposure on FLCN production was investigated by treating HAECs (A549 cells) with TDIhuman serum albumin conjugate, which showed increased expression and release of FLCN and interleukin-8 from HAECs. Coculture with peripheral blood neutrophils also induced FLCN expression and release from HAECs. In conclusion, TDI exposure and TDI-induced neutrophil recruitment into the airways can activate and stimulate HAECs to produce FLCN, which could be involved in airway inflammation in workers exposed to TDI.
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참고문헌 (19)
참고문헌 신청
Busse PJ / 2010 / Age-related changes in immune function : Effect on airway inflammation / J Allergy Clin Immunol 126 : 690 ~ 699
Choi JH / 2004 / Increased levels of IgG to cytokeratin 19 in sera of patients with toluene diisocyanateinduced asthma / Ann Allergy Asthma Immunol 93 : 293 ~ 298
Goncharova EA / 2014 / Folliculin controls lung alveolar enlargement and epithelial cell survival through E-cadherin, LKB1, and AMPK / Cell Rep 7 : 412 ~ 423
Holgate ST / 2000 / Bronchial epithelium as a key regulator of airway allergen sensitization and remodeling in asthma / Am J Respir Crit Care Med 162 : 113 ~ 117
Hoshika Y / 2016 / Haploinsufficiency of the folliculin gene leads to impaired functions of lung fibroblasts in patients with Birt-Hogg-Dube syndrome / Physiol Rep 4 : 13025
Choi JH / 2004 / Increased levels of IgG to cytokeratin 19 in sera of patients with toluene diisocyanateinduced asthma / Ann Allergy Asthma Immunol 93 : 293 ~ 298
Goncharova EA / 2014 / Folliculin controls lung alveolar enlargement and epithelial cell survival through E-cadherin, LKB1, and AMPK / Cell Rep 7 : 412 ~ 423
Holgate ST / 2000 / Bronchial epithelium as a key regulator of airway allergen sensitization and remodeling in asthma / Am J Respir Crit Care Med 162 : 113 ~ 117
Hoshika Y / 2016 / Haploinsufficiency of the folliculin gene leads to impaired functions of lung fibroblasts in patients with Birt-Hogg-Dube syndrome / Physiol Rep 4 : 13025
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