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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1 - 8 (8page)
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Owing to the worldwide obesity epidemic and the sedentary lifestyle in industrialized countries, the number of people with metabolic diseases is explosively increasing. Magnetic resonance spectroscopy (MRS), which is fundamentally similar to magnetic resonance imaging, can detect metabolic changes in vivo noninvasively. With its noninvasive nature, 1H, 13C and 31P MRS are being actively utilized in clinical and biomedical metabolic studies to detect lipids and important metabolites without ionizing radiation. 1H MRS can quantify lipid content in liver and muscle and can detect other metabolites, such as 2-hydroxyglutarate, in vivo. Of interest, many studies have indicated that hepatic and intramyocellular lipid content is inversely correlated with insulin sensitivity in humans. Thus, lipid content can be utilized as an in vivo biomarker for detecting early insulin resistance. Employing 13C MRS, hepatic glycogen synthesis and breakdown can be directly detected, whereas 31P MRS provides in vivo adenosine triphosphate (ATP) synthesis rates by saturation transfer methods in addition to ATP content. These in vivo data can be very difficult to assess by other methods and offer a critical piece of metabolic information. To aid the reader in understanding these new methods, fundamentals of MRS are described in this review in addition to promising futureapplications of MRS and its limitations.
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참고문헌 (23)
참고문헌 신청
Burt CT / 1976 / Analysis of phosphate metabolites, the intracellular pH, and the state of adenosine triphosphate in intact muscle by phosphorus nuclear magnetic resonance /
Gadian DG / 1976 / Phosphorus nuclear magnetic resonance studies on normoxic and ischemic cardiac tissue / Proc Natl Acad Sci USA 73 : 4446 ~ 4448
Hwang J-H / 2007 / Increased intrahepatic triglyceride is associated with peripheral insulin resistance: in vivo MR imaging and spectroscopy studies / Am J Physiol Endocrinol
Insull W / 1969 / Studies of arteriosclerosis in Japanese and American men: I. Comparison of fatty acid composition of adipose tissue / J Clin Invest 48 : 1313 ~ 1327
Kang JX / 1997 / Regulation of sodium channel gene expression by class I antiarrhythmic drugs and n-3 polyunsaturated fatty acids in cultured neonatal rat cardiac myocytes /
Gadian DG / 1976 / Phosphorus nuclear magnetic resonance studies on normoxic and ischemic cardiac tissue / Proc Natl Acad Sci USA 73 : 4446 ~ 4448
Hwang J-H / 2007 / Increased intrahepatic triglyceride is associated with peripheral insulin resistance: in vivo MR imaging and spectroscopy studies / Am J Physiol Endocrinol
Insull W / 1969 / Studies of arteriosclerosis in Japanese and American men: I. Comparison of fatty acid composition of adipose tissue / J Clin Invest 48 : 1313 ~ 1327
Kang JX / 1997 / Regulation of sodium channel gene expression by class I antiarrhythmic drugs and n-3 polyunsaturated fatty acids in cultured neonatal rat cardiac myocytes /
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