지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1 - 10 (10page)
이용수
초록· 키워드
오류제보하기
The primary purpose of this study was to explore the short-term efficacy of different cisplatin and fluorouracil-based chemotherapy regimens in the treatment of patients with esophagogastric junctional adenocarcinoma (EGJA) using a network meta-analysis (NMA). Randomized controlled trials (RCTs) related to chemotherapy regimens based on cisplatin and fluorouracil for EGJA were included from the PubMed, EMBASE and Cochrane Library electronic databases (from inception to June 2016).
Direct and indirect evidence were combined to calculate the pooled odds ratio (OR) and its 95% confidence interval (95% CI) as well as to draw the surface under the cumulative ranking (SUCRA) curves. This NMA finally enrolled ten eligible RCTs with the following five regimens: cisplatin plus fluorouracil (cisplatin+fluorouracil), cisplatin+fluorouracil-based chemotherapy (cisplatin+fluorouracil+docetaxel/epirubicin/irinotecan), fluorouracil-based chemotherapy (fluorouracil+docetaxel/doxorubicin/ methotrexate/irinotecan), cisplatin-based chemotherapy (cisplatin+docetaxel/epirubicin/irinotecan/capecitabine/s-1) and other drug-based chemotherapy (docetaxel/irinotecan/capecitabine). These results revealed that compared with a cisplatin+ fluorouracil-based chemotherapy regimen, the fluorouracil-based chemotherapy regimen had a lower overall response rate (ORR) and partial response (PR) for EGJA patients (ORR: OR=0.43, 95% CI=0.22–0.86; PR: OR=0.46, 95% CI=0.23–0.91).
Cluster analyses suggested that the cisplatin+fluorouracil-based chemotherapy regimen had the best short-term efficacy for EGJA in terms of the complete response (CR), PR, ORR, stable disease (SD) and progression disease (PD). Our results indicated that cisplatin+fluorouracil-based chemotherapy regimens may have the best short-term efficacy in the treatment of EGJA
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Bamal R / 2014 / Evaluation and validation of neo-adjuvant response index(NRI)and it's correlation with various predictive biomarkers and RECIST in locally advanced breast c
Blot WJ / 1991 / Rising incidence of adenocarcinoma of the esophagus and gastric cardia / JAMA 265 : 1287 ~ 1289
Botterweck AA / 2000 / Trends in incidence of adenocarcinoma of the oesophagus and gastric cardia in ten European countries / Int J Epidemiol 29 : 645 ~ 654
Buas MF / 2013 / Epidemiology and risk factors for gastroesophageal junction tumors : understanding the rising incidence of this disease / Semin Radiat Oncol 23 : 3 ~ 9
Casagrande N / 2014 / Preclinical activity of the liposomal cisplatin lipoplatin in ovarian cancer / Clin Cancer Res 20 : 5496 ~ 5506
Blot WJ / 1991 / Rising incidence of adenocarcinoma of the esophagus and gastric cardia / JAMA 265 : 1287 ~ 1289
Botterweck AA / 2000 / Trends in incidence of adenocarcinoma of the oesophagus and gastric cardia in ten European countries / Int J Epidemiol 29 : 645 ~ 654
Buas MF / 2013 / Epidemiology and risk factors for gastroesophageal junction tumors : understanding the rising incidence of this disease / Semin Radiat Oncol 23 : 3 ~ 9
Casagrande N / 2014 / Preclinical activity of the liposomal cisplatin lipoplatin in ovarian cancer / Clin Cancer Res 20 : 5496 ~ 5506
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
In-vitro elution of cisplatin and fluorouracil from bi-layered biodegradable beads
Biomaterials and biomedical engineering
2015 .01
-
Resveratrol enhances cisplatin-induced apoptosis in human hepatoma cells via glutamine metabolism inhibition
BMB Reports
2018 .01
-
API5 induces cisplatin resistance through FGFR signaling in human cancer cells
Experimental and Molecular Medicine
2017 .01
-
Identification of a novel PARP4 gene promoter CpG locus associated with cisplatin chemoresistance
BMB Reports
2023 .06
-
MiR-363 inhibits cisplatin chemoresistance of epithelial ovarian cancer by regulating snail-induced epithelial-mesenchymal transition
BMB Reports
2018 .01
-
Multi-layered Microfluidic Drug Screening Platform Enabling Simultaneous Generation of Linear and Logarithmic Concentration Gradients
BioChip Journal
2024 .09
-
miR-638 is a new biomarker for outcome prediction of non-small cell lung cancer patients receiving chemotherapy
Experimental and Molecular Medicine
2015 .01
-
Coordinative Double Hydrophilic Polyether Micelle for Controlled Delivery of Cisplatin
한국고분자학회 학술대회 연구논문 초록집
2023 .04
-
Pre-activation of HIF-1α Using PHD Inhibitor Reduces Cisplatin-induced Nephrotoxicity
한국생물공학회 학술대회
2021 .10
-
Combination Cancer Treatment of Chemotherapy and Photodynamic Therapy Using Albumin Nanoparticle
한국생물공학회 학술대회
2020 .10
-
Tannic acid-cisplatin Complex Mediated Self-Assembly of Nanogel Structure with Pyrene-Modified Chitosan for Enhanced Anticancer Efficacy and Colloidal Stability
한국고분자학회 학술대회 연구논문 초록집
2022 .04
-
Upregulation of Fas in epithelial ovarian cancer reverses the development of resistance to Cisplatin
BMB Reports
2015 .01
-
Regulation of IL-6 signaling by miR-125a and let-7e in endothelial cells controls vasculogenic mimicry formation of breast cancer cells
BMB Reports
2019 .01
-
RNA-based Predictive Marker for Chemotherapy
한국생물공학회 학술대회
2022 .09
-
Cancer cells undergoing epigenetic transition show short-term resistance and are transformed into cells with medium-term resistance by drug treatment
Experimental and Molecular Medicine
2020 .01
-
Chemical Inhibition of Cell Recovery after Irradiation with Sparsely and Densely Ionizing Radiation
방사선산업학회지
2016 .01
-
Overcoming the Drug Resistance with Combination Effect of Ultrasound-mediated Chemotherapy and Photodynamic Therapy
한국고분자학회 학술대회 연구논문 초록집
2019 .04
-
항암화학요법을 받은 대장암환자의 증상, 피로 및 삶의 질의 종단적 경로분석
보건정보통계학회지
2018 .01
-
Fabrication of core/Shell Structural Nanofibers to Control the drug Release as Chemotherapy for Tumor Treatment
한국정밀공학회 학술발표대회 논문집
2019 .05
-
Antitumor Efficacy of Docetaxel-loaded Multi-layered Nanoparticles
한국생물공학회 학술대회
2017 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0