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- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
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Esophageal squamous cell carcinoma (ESCC) is a deadly malignancy with regard to mortality and prognosis, and the 5-year survival rate for all patients diagnosed with ESCC remains poor. A better understanding of the biological mechanisms of ESCC tumorigenesis and progression is of great importance to improve treatment of this disease. In this study, we demonstrated that the glutathione metabolism pathway is highly enriched in ESCC cells compared with normal esophageal epithelial cells in an in vivo mouse model. In addition, treatment with L-buthionine-sulfoximine (BSO) to deplete glutathione decreased the ESCC tumor burden in mice, thus demonstrating the critical role of glutathione metabolism in ESCC progression. BSO treatment also led to decreased cell proliferation and activation of cell apoptosis in ESCC. Finally, BSO treatment blocked NF-kB pathway activation in ESCC. Our study reveals a new pathway that regulates ESCC progression and suggests that inhibition of glutathione metabolism may be a potential strategy for ESCC treatment
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참고문헌 (22)
참고문헌 신청
Budnick I / 2016 / Defining the identity of mouse embryonic dermal fibroblasts / Genesis 54 : 415 ~ 430
Chen D / 2012 / Dermal beta-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation / Development 139 : 1
Chen W / 2015 / The updated incidences and mortalities of major cancers in China, 2011 / Chin J Cancer 34 : 502 ~ 507
Dong Y / 2017 / Effect of gelatin sponge with colloid silver
Gao CM / 2002 / Glutathione-S-transferases M1 (GSTM1) and GSTT1 genotype, smoking, consumption of alcohol and tea and risk of esophageal and stomach cancers: a case-control s
Chen D / 2012 / Dermal beta-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation / Development 139 : 1
Chen W / 2015 / The updated incidences and mortalities of major cancers in China, 2011 / Chin J Cancer 34 : 502 ~ 507
Dong Y / 2017 / Effect of gelatin sponge with colloid silver
Gao CM / 2002 / Glutathione-S-transferases M1 (GSTM1) and GSTT1 genotype, smoking, consumption of alcohol and tea and risk of esophageal and stomach cancers: a case-control s
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