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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
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- 1 - 9 (9page)
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Neointimal proliferation after vascular injury is a key mechanism of restenosis, a major cause of percutaneous transluminal angioplasty failure and artery bypass occlusion. Emodin, an anthraquinone with multiple physiological activities, has been reported to inhibit proliferation of vascular smooth muscle cells (VSMCs) that might cause intimal arterial thickening. Thus, in this study, we established a rat model of balloon-injured carotid artery and investigated the therapeutic effect of emodin and its underlying mechanism. Intimal thickness was analyzed by hematoxylin and eosin staining. Expression of Wnt4, dvl-1, β-catenin and collagen was determined by immunohistochemistry and/or western blotting. The proliferation of VSMC was evaluated by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay and electron microscopy. MicroRNA levels were quantified by real-time quantitative PCR. Emodin relieved injury-induced artery intimal thickness. Results of western blots and immunohistochemistry showed that emodin suppressed expression of signaling molecules Wnt4/Dvl-1/β-catenin as well as collagen protein in the injured artery. In addition, emodin enhanced expression of an artery injury-related microRNA, miR-126. In vitro, MTT assay showed that emodin suppressed angiotensin II (AngII)-induced proliferation of VSMCs. Emodin reversed AngII-induced activation of Wnt4/Dvl-1/β-catenin signaling by increasing expression of miR-126 that was strongly supported by transfection of mimic or inhibitor for miR-126. Emodin prevents intimal thickening via Wnt4/Dvl-1/β-catenin signaling pathway mediated by miR-126 in balloon-injured carotid artery of rats.
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참고문헌 (23)
참고문헌 신청
Caporali A / 2011 / MicroRNA regulation in angiogenesis / Vascul Pharmacol 55 : 79 ~ 86
He L / 2012 / Effects of emodin extracted from Chinese herbs on proliferation of non-small cell lung cancer and underlying mechanisms / Asian Pac J Cancer Prev 13 : 1505 ~ 15
Heo SK / 2008 / Emodin inhibits TNF-alpha-induced human aortic smooth-muscle cell proliferation via caspase-and mitochondrial-dependent apoptosis / J Cell Biochem 105 : 70 ~
Li PP / 2013 / Role of signaling pathways and miRNAs in chronic lymphocytic leukemia / Chin Med J (Engl) 126 : 4175 ~ 4182
Lin SZ / 2012 / Antitumor activity of emodin against pancreatic cancer depends on its dual role:promotion of apoptosis and suppression of angiogenesis / PLoS One 7 : e42146 ~
He L / 2012 / Effects of emodin extracted from Chinese herbs on proliferation of non-small cell lung cancer and underlying mechanisms / Asian Pac J Cancer Prev 13 : 1505 ~ 15
Heo SK / 2008 / Emodin inhibits TNF-alpha-induced human aortic smooth-muscle cell proliferation via caspase-and mitochondrial-dependent apoptosis / J Cell Biochem 105 : 70 ~
Li PP / 2013 / Role of signaling pathways and miRNAs in chronic lymphocytic leukemia / Chin Med J (Engl) 126 : 4175 ~ 4182
Lin SZ / 2012 / Antitumor activity of emodin against pancreatic cancer depends on its dual role:promotion of apoptosis and suppression of angiogenesis / PLoS One 7 : e42146 ~
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