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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 458 - 468 (11page)
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Na+-Ca2+ exchanger (NCX) transports Ca2+ coupled with Na+ across the plasma membrane in a bi-directional mode. Ca2+ flux via NCX mediates osteogenic processes, such as formation of extracellular matrix proteins and bone nodules. However, it is not clearly understood how the NCX regulates cellular Ca2+ movements in osteogenic processes. In this study, the role of NCX in modulating Ca2+ content of intracellular stores ([Ca2+]ER) was investigated by measuring intracellular Ca2+ activity in isolated rat osteoblasts. Removal of extracellular Na+ elicited a transient increase of intracellular Ca2+ concentration ([Ca2+]i). Pretreatment of antisense oligodeoxynucleotide (AS) against NCX depressed this transient Ca2+ rise and raised the basal level of [Ca2+]i. In AS-pretreated cells, the expression and activity of alkaline phosphatase (ALP), an osteogenic marker, were decreased. However, the cell viability was not affected by AS-pretreatment. Suppression of NCX activity by the AS-pretreatment decreased ATP-activated Ca2+ release from intracellular stores and significantly enhanced Ca2+ influx via store operated calcium influx (SOCI), compared to those of S-pretreated or control cells. These results strongly suggest that NCX has a regulatory role in cellular Ca2+ pathways in osteoblasts by modulating intracellular Ca2+ content.
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참고문헌 (24)
참고문헌 신청
Adebanjo OA / 2000 / Novel biochemical and functional insights into nuclear Ca(2+) transport through IP(3)Rs and RyRs in osteoblasts 278 : 784 ~ 791
Arakawa N / 2000 / KB-R7943 inhibits store-operated Ca(2+) entry in cultured neurons and astrocytes 279 : 354 ~ 357
Baldi C / 2003 / TRPC3-like protein is involved in the capacitative cation entry induced by 1alpha,25-dihydroxy-vitamin D3 in ROS 17/2.8 osteoblastic cells 90 : 197 ~ 205
Bancroft GN / 2002 / Fluid flow increases mineralized matrix deposition in 3D perfusion culture of marrow stromal osteoblasts in a dose-dependent manner 99 : 12600 ~ 12605
Berridge MJ / 2002 / The endoplasmic reticulum: a multifunctional signaling organelle 32 : 235 ~ 249
Arakawa N / 2000 / KB-R7943 inhibits store-operated Ca(2+) entry in cultured neurons and astrocytes 279 : 354 ~ 357
Baldi C / 2003 / TRPC3-like protein is involved in the capacitative cation entry induced by 1alpha,25-dihydroxy-vitamin D3 in ROS 17/2.8 osteoblastic cells 90 : 197 ~ 205
Bancroft GN / 2002 / Fluid flow increases mineralized matrix deposition in 3D perfusion culture of marrow stromal osteoblasts in a dose-dependent manner 99 : 12600 ~ 12605
Berridge MJ / 2002 / The endoplasmic reticulum: a multifunctional signaling organelle 32 : 235 ~ 249
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