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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 553 - 564 (12page)
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In cancer gene therapy, restriction of antitumor transgene expression in a radiation field by use of ionizing radiation-inducible promoters is one of the delivery. Although tumor suppressor protein p53 is induced by low doses (＜ 1 Gy) of radiation, there have been only a few reports indicating potential utilization of a p53-target gene promoter, such as that of the p21 gene. This is mainly because the transiently transfected promoter of p53-target genes is not much sensitive to radiation. We examined the response of the p21 gene promoter to low-dose radiation when transduced into a human breast cancer cell line MCF-7 by use of recombinant adeno-associated virus (rAAV) vectors. It was shown that the p21 gene promoter transduced by rAAV vectors was more highly radiation-responsive than that transiently tion of the p21 gene promoter by radiation of low doses down to 0.2 Gy was observed. When cells were transduced with the p21 gene promoter-driven HSVtk gene by rAAV vector, they were significantly sensitized to repetitive treatment with low dose radiation (1 Gy) in the presence of the prodrug ganciclovir. It was therefore considered that the p21 gene promoter in combination with a rAAV vector is potentially usable for the development of a low-dose radiation-inducible vector for cancer gene therapy.
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참고문헌 (28)
참고문헌 신청
[
/ / Allred DC. p53 is mutated in a subset of advanced-stage prostate cancers. Cancer Res 1993;53 : 3369 ~ 73
/ / Harris CC. p53 mutations in human cancers. Science 1991;253 : 49 ~ 53
/ / Liu ET. Alterations of the p53 gene are associated with the progression of a human prostate carcinoma. J Urol 1992;147 : 789 ~ 93
/ / a potential mediator of p53 tumor suppression. Cell 1993;75 toki (t) : 817 ~ 25
/ / Allred DC. p53 is mutated in a subset of advanced-stage prostate cancers. Cancer Res 1993;53 : 3369 ~ 73
/ / Harris CC. p53 mutations in human cancers. Science 1991;253 : 49 ~ 53
/ / Liu ET. Alterations of the p53 gene are associated with the progression of a human prostate carcinoma. J Urol 1992;147 : 789 ~ 93
/ / a potential mediator of p53 tumor suppression. Cell 1993;75 toki (t) : 817 ~ 25
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