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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 319 - 326 (8page)
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To identify immunoglobulin variable heavy chain (VH)gene usages in Korean ankylosing spondylitis (AS) patients,expression level of VH2 genes from peripheral blood mononuclear cells (PBMCs) of 8 AS patients and 9 healthy donors was analysed by quantitative real-time PCR (Q-PCR). Q-PCR results demonstrated VH2 genes were overexpressed in AS patients (Relative amount of mRNA of VH2 genes to a house-keeping gene, 7.13 ± 7.77 vs, 0.68 ± 0.55; P ＜ 0.0001). The sequence analysis revealed the majority of them contained CDC42 binding protein kinase beta (CDC42 BPB) genes. The insertion of CDC42 BPB gene was confirmed by PCR with primers corresponding CDC42 BPB and CH genes. Our study revealed VH2overexpression and unique rearrangement in Ig VH genes from peripheral blood of AS patients. This may imply aberrant immunoglobulin gene rearrangement in B cell occurs in Korean AS patients, which requires further investigation.
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참고문헌 (25)
참고문헌 신청
Appel H / 2006 / Immunohistologic analysis of zygapophyseal joints in patients with ankylosing spondylitis / Arthritis Rheum 54 : 2845 ~ 2851
Baeten D / 2002 / Macrophages expressing the scavenger receptor CD163: a link between immune alterations of the gut and synovial inflammation in spondyloarthropathy / J Patho
Breban M / 1996 / T cells, but not thymic exposure to HLA-B27, are required for the inflammatory disease of HLA-B27 transgenic rats / J Immunol 156 : 794 ~ 803
Brewerton DA / 1973 / Ankylosing spondylitis and HL-A 27 / Lancet 1 : 904 ~ 907
Cook GP / 1994 / A map of the human immunoglobulin VH locus completed by analysis of the telomeric region of chromosome 14q / Nat Genet 7 : 162 ~ 168
Baeten D / 2002 / Macrophages expressing the scavenger receptor CD163: a link between immune alterations of the gut and synovial inflammation in spondyloarthropathy / J Patho
Breban M / 1996 / T cells, but not thymic exposure to HLA-B27, are required for the inflammatory disease of HLA-B27 transgenic rats / J Immunol 156 : 794 ~ 803
Brewerton DA / 1973 / Ankylosing spondylitis and HL-A 27 / Lancet 1 : 904 ~ 907
Cook GP / 1994 / A map of the human immunoglobulin VH locus completed by analysis of the telomeric region of chromosome 14q / Nat Genet 7 : 162 ~ 168
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