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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 191 - 202 (12page)
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Objectives: The purpose of this study was to examine the anti-depressive effects of BanHaHuBakTang-kami (BHHBT) on an animal model of depression induced by chronic immobility stress.Methods: Mice were treated daily with immobilization stress for 2 hours over a period of 21 days. To examine the effect of BHHBT, we performed behavioral, biochemical and histological analysis to meas-ure immobility time (FST), brain neurotransmitter concentration (HPLC, ELISA), hippocampal damage (H&E staining) and CRF-R1 expression (immunohistochemistry).Results: BHHBT has reduced the immobility time of immobilization stress exposed mice in the forced swimming test. BHHBT has increased the amount of serotonin in the brain. BHHBT has increased the expression level of serotonin in the brain. BHHBT 540 mg/kg were sufficient to prevent tissue damage in the hippocampus region. BHHBT has reduced the expression level of CRF receptors in the hippo-campus region.Conclusions: These results suggest that BHHBT may have anti-depressive effects on mice treated with immobilization stress by reducing immobility, increasing brain serotonin concentration and reducing CRF-R1 expression in the hippocampus region.
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참고문헌 (31)
참고문헌 신청
[학술지(정기간행물)]
Bear MF / 2009 / Neuroscience:Exploring the Brain / Biomedibook
Choi EM / 2001 / Possibility of regulation by food in depression and mood disorders / Food science and industry 34 (4) : 53 ~ 69
Ganguly, S. / 2002 / Control of melatonin synthesis in the mammalian pineal gland : the critical role of serotonin acetylation / Cell Tissue Res 309 : 127 ~ 137
Guo Y / 2004 / Antidepressant evaluation of polysaccharides from a Chinese herbal medicine Banxia-houpu decoction / Phytother Res 18 (3) : 204 ~ 207
Bear MF / 2009 / Neuroscience:Exploring the Brain / Biomedibook
Choi EM / 2001 / Possibility of regulation by food in depression and mood disorders / Food science and industry 34 (4) : 53 ~ 69
Ganguly, S. / 2002 / Control of melatonin synthesis in the mammalian pineal gland : the critical role of serotonin acetylation / Cell Tissue Res 309 : 127 ~ 137
Guo Y / 2004 / Antidepressant evaluation of polysaccharides from a Chinese herbal medicine Banxia-houpu decoction / Phytother Res 18 (3) : 204 ~ 207
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