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Mitogen-activated protein kinases (MAPKs) are one of the most important enzymes in various cellular activities, andthe MAPK signaling pathway is implicated in many disorders. MAPK phosphatases (MKPs) are regulators that contain aMAPK-binding domain (MBD) for MAPK recognition, and a catalytic domain (CD), for dephosphorylation and inactivationof MAPKs. Due to their crucial role in regulating the MAPK pathway, MKPs are regarded as a potential drug target invarious diseases. Attempts have also been made to regulate the MAPK pathway by reducing the MKP activity. For drugdevelopment, it is important to understand the key features of MAPK-MKP complex formation. This review summarizes thestudies on MAPK-MKP complexes, mainly focusing on their selective recognition and catalytic activation.
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참고문헌 (32)
참고문헌 신청
Camps, M / 1998 / Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase / Science 280:1262~1265
Chen, P / 2001 / Discordance between the binding affinity of mitogen-activated protein kinase subfamily members for MKP-2 and their ability to catalytically activate the phosphatase / J Biol Chem 276:29440~29449
Dechert, U / 1994 / Characterization of protein tyrosine phosphatase SH-PTP2. Study of phosphopeptide substrates and possible regulatory role of SH2 domains / J Biol Chem 269:5602~5611
Farooq, A / 2001 / Solution structure of ERK2 binding domain of MAPK phosphatase MKP-3 : structural insights into MKP-3 activation by ERK2 / Mol Cell 7:387~399
Farooq, A / 2004 / Structure and regulation of MAPK phosphatases / Cell Signal 16:769~779
Chen, P / 2001 / Discordance between the binding affinity of mitogen-activated protein kinase subfamily members for MKP-2 and their ability to catalytically activate the phosphatase / J Biol Chem 276:29440~29449
Dechert, U / 1994 / Characterization of protein tyrosine phosphatase SH-PTP2. Study of phosphopeptide substrates and possible regulatory role of SH2 domains / J Biol Chem 269:5602~5611
Farooq, A / 2001 / Solution structure of ERK2 binding domain of MAPK phosphatase MKP-3 : structural insights into MKP-3 activation by ERK2 / Mol Cell 7:387~399
Farooq, A / 2004 / Structure and regulation of MAPK phosphatases / Cell Signal 16:769~779
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