지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 영남대학교 의과대학 Journal of Yeungnam Medical Science Yeungnam University Journal of Medicine 제35권 제2호
- 발행연도
- 2018.1
- 수록면
- 213 - 218 (6page)
이용수
초록· 키워드
오류제보하기
Background: Body fats, especially both of abdominal fat pad mass and skeletal muscle fat content, are inversely related to insulin action. Therefore, methods for decreasing visceral fat mass and muscle triglyceride content may be helpful for the prevention of insulin resistance. Methods: Thalidomide, used for its anti-angiogenic and anti-inflammatory properties, was administered to rats for 4 weeks. A 10% solution of thalidomide in dimethyl sulfoxide was injected daily into the peritoneal cavity as much as 100 mg/kg of body weight. Results: The total visceral fat pad mass in the thalidomide-treated group was 11% lower than in the control group. The size of adipocytes of the epididymal fat pad mass in the thalidomide-treated group was smaller than in the control group. The intraperitoneal thalidomide treatment increased triglyceride concentrations by 16% in the red muscle, but not in the white muscle. Conclusion: The results suggested that intraperitoneal thalidomide treatment inhibited abdominal fat accumulation, and that the free fatty acids in the blood were preferentially accumulated in the red muscle rather than in the white muscle.
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등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Kim JY / 2000 / High-fat diet-induced muscle insulin resistance:relationship to visceral fat mass / Am J Physiol Regul Integr Comp Physiol 279:R2057~R2065
Kim JY / 1999 / Insulin resistance of muscle glucose transport in male and female rats fed a high-sucrose diet / Am J Physiol 276:R665~R672
Jacob S / 1999 / Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects / Diabetes 48:1113~1119
Krssak M / 1999 / Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study / Diabetologia 42:113~116
D'Amato RJ / 1994 / Thalidomide is an inhibitor of angiogenesis / Proc Natl Acad Sci U S A 91:4082~4085
Kim JY / 1999 / Insulin resistance of muscle glucose transport in male and female rats fed a high-sucrose diet / Am J Physiol 276:R665~R672
Jacob S / 1999 / Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects / Diabetes 48:1113~1119
Krssak M / 1999 / Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study / Diabetologia 42:113~116
D'Amato RJ / 1994 / Thalidomide is an inhibitor of angiogenesis / Proc Natl Acad Sci U S A 91:4082~4085
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