지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Background : Palivizumab is an intravenous monoclonal antibody which is used in the prevention of respiratory syncytial virus (RSV) infection. It is currently recommended for infants who are at high-risk for RSV infections due to preterm birth or other medical conditions such as congenital heart disease. Palivizumab is a humanized monoclonal antibody directed against an epitope in the antigenic site A of the protein F of RSV particles. Palivizumab is given once a month via intramuscular (IM) injection throughout the duration of the RSV season. Since palivizumab is known to have preventive effects against RSV infection for children with older siblings, the insurance coverage for palivizumab was expanded in October 2016. Methods : The electronic medical records of children under 2 years old who have older siblings who visited or were admitted to the Severance Hospital from October 2015 to May 2016 and from October 2016 to May 2017 were reviewed retrospectively. The data were then divided into two groups depending on the pilivizumab administration. Results : A total of 67 patients were enrolled in this study. The effectiveness in the reduction of hospitalization was statistically significant (p=0.009). Palivizumab decreased respiratory symptoms such as cough, rhinorrhea, and fever in patients with older siblings (p 0.05). Conclusions : In this study, palivizumab administration was effective in preventing RSV infection in infants with older siblings. Expanding palivizumab-prophylaxis administration to infants with older siblings may be effective in the prevention of upper respiratory infections.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Park HW / 2012 / Epidemiology of respiratory syncytial virus infection in infants born at less than thirty-five weeks of gestational age / Pediatr Infect Dis J 31(8):e99~e104
Lee YI / 2016 / Risk factors for acute respiratory syncytial virus infection of lower respiratory tract in hospitalized infants / J Microbiol Immunol Infect 49(5):737~742
Krisna N.A. Pangesti / 2018 / Molecular epidemiology of respiratory syncytial virus / Reviews in Medical Virology 28(2):e1968
Thorburn K / 2012 / Mortality and morbidity of nosocomial respiratory syncytial virus (RSV) infection in ventilated children-A ten year perspective / Minerva Anestesiol 78(7):782~789
Rose EB / 2018 / Respiratory Syncytial Virus Seasonality - United States, 2014-2017 / MMWR Morb Mortal Wkly Rep 67(2):71~76
Lee YI / 2016 / Risk factors for acute respiratory syncytial virus infection of lower respiratory tract in hospitalized infants / J Microbiol Immunol Infect 49(5):737~742
Krisna N.A. Pangesti / 2018 / Molecular epidemiology of respiratory syncytial virus / Reviews in Medical Virology 28(2):e1968
Thorburn K / 2012 / Mortality and morbidity of nosocomial respiratory syncytial virus (RSV) infection in ventilated children-A ten year perspective / Minerva Anestesiol 78(7):782~789
Rose EB / 2018 / Respiratory Syncytial Virus Seasonality - United States, 2014-2017 / MMWR Morb Mortal Wkly Rep 67(2):71~76
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