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논문 기본 정보

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학술저널
저자정보
Na Bonhyang (Department of Pediatrics, Severance Children’s Hospital, Yonsei University College of Medicine, Seoul, Korea.Institute for Immunology and Immunological Diseases, Yonsei University College of) Park Yu Jin (Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.) Seo Jieun (Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.) Park Miri (Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.) Baek Jee Yeon (Department of Pediatrics, Severance Children’s Hospital, Yonsei University College of Medicine, Seoul, Korea.) Lee Ji Young (Department of Pediatrics, Severance Children’s Hospital, Yonsei University College of Medicine, Seoul, Korea.) Kim Minyoung (Department of Pediatrics, Severance Children’s Hospital, Yonsei University College of Medicine, Seoul, Korea.Institute for Immunology and Immunological Diseases, Yonsei University College of) Ahn Jong Gyun (Department of Pediatrics, Severance Children’s Hospital, Yonsei University College of Medicine, Seoul, Korea.Institute for Immunology and Immunological Diseases, Yonsei University College of) Lee Seung Tae (Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.Dxome Co., Ltd., Seongnam, Korea.) Kang Ji-Man (Department of Pediatrics, Severance Children’s Hospital, Yonsei University College of Medicine, Seoul, Korea.Institute for Immunology and Immunological Diseases, Yonsei University College of)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.39 No.28
발행연도
2024.7
수록면
1 - 12 (12page)
DOI
10.3346/jkms.2024.39.e206

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Background: Respiratory syncytial virus (RSV), a highly transmissible virus, is the leading cause of lower respiratory tract infections. We examined molecular changes in the RSV genome before and after the coronavirus disease 2019 (COVID-19) pandemic in Korea, and investigated whether drug-resistant mutations were present. Methods: In this prospective, single-center study, RSV-positive respiratory samples were collected between September 2019 and December 2022. Long-read whole-genome sequencing (WGS) was performed, and the presence of known drug-resistant substitutions for palivizumab, nirsevimab, and suptavumab was investigated. Results: Overall, 288 respiratory samples were collected from 276 children. WGS data were available for 133 samples (71 and 62 samples from the pre- and post-pandemic periods, respectively). All RSV-A strains (n = 56) belonged to the GA2.3.5 (ON1) genotype, whereas all RSV-B strains (n = 77) belonged to the GB5.0.5a (BA) genotype. No significant differences in genotypes were observed between the pre- and post-pandemic periods. In addition, no notable mutations related to nirsevimab or palivizumab resistance were detected in the F gene. However, the L172Q and S173L substitutions, which are known to confer resistance to suptavumab, were present in all RSV-B samples. Conclusion: Despite the unprecedented interruption of RSV seasonality, there were no significant molecular changes in circulating RSV strains in Korea related to nirsevimab or palivizumab resistance before and after the COVID-19 pandemic. However, RSV-specific drug-resistance substitutions for suptavumab were identified.
#RSV #Genotype #Whole-Genome Sequencing #Resistance #Palivizumab #Nirsevimab #Suptavumab #COVID-19 Pandemic #Children #Korea

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