지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Transforming growth factor-β (TGF-β) is a cytokine that plays an important role in both normal joints and joints affected by osteoarthritis (OA), the most common joint disease. However, the role of this pleiotropic cytokine in a normal healthy joint is very different from its role in an OA joint. In a normal synovial joint, active TGF-β is only present after joint loading and only for a short period. In contrast, permanent and high levels of active TGF-β are detected in OA joints. Due to this difference in levels and exposure period of joint cells to active TGF-β, the function of TGF-β is strikingly different in normal and OA joints. The consequences of this difference in TGF-β levels on joint homeostasis and pathological changes in OA joints are discussed in this review.
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참고문헌 (68)
참고문헌 신청
Wallace IJ / 2017 / Knee osteoarthritis has doubled in prevalence since the mid-20th century / Proc Natl Acad Sci U S A 114:9332~9336
Newfeld SJ / 1999 / Molecular evolution of a developmental pathway: phylogenetic analyses of transforming growth factor-beta family ligands, receptors and Smad signal transducers / Genetics 152:783~795
Dickson MC / 1995 / Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice / Development 121:1845~1854
Kulkarni AB / 1993 / Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death / Proc Natl Acad Sci U S A 90:770~774
Shull MM / 1992 / Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease / Nature 359:693~699
Newfeld SJ / 1999 / Molecular evolution of a developmental pathway: phylogenetic analyses of transforming growth factor-beta family ligands, receptors and Smad signal transducers / Genetics 152:783~795
Dickson MC / 1995 / Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice / Development 121:1845~1854
Kulkarni AB / 1993 / Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death / Proc Natl Acad Sci U S A 90:770~774
Shull MM / 1992 / Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease / Nature 359:693~699
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