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Treatment of Osteoporosis: Unmet Needs and Emerging Solutions
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논문 기본 정보

Type
Academic journal
Author
Journal
The Korean Society of Bone Metabolism 대한골대사학회지 대한골대사학회지 제25권 제3호 KCI Accredited Journals
Published
2018.1
Pages
133 - 140 (8page)

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Treatment of Osteoporosis: Unmet Needs and Emerging Solutions
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Abstract· Keywords

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Efficient therapies are available for the treatment of osteoporosis, however, there are still unmet needs. Anti-resorptive therapies only increase bone mineral density to a certain extent and reduce the risk of non-vertebral fractures by 20%, only one anabolic option is available in most parts of the world –the effect of which levels off over time, and the evidence for combination therapy targeting both resorption and formation is limited. In addition, identification and treatment of patients with high and imminent fracture risk following a recent fracture and long-term adherence to treatment are 2 other very prominent challenges to the management of osteoporosis. The current review will focus on emerging osteoporosis treatments and optimized use of the existing treatments that may help overcome the currently unmet needs in the management of osteoporosis.

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References (43)

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Johnell O / 2005 / Predictive value of BMD for hip and other fractures / J Bone Miner Res 20:1185~1194 Crossref Strom O / 2011 / Osteoporosis: burden, health care provision and opportunities in the EU: a report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA) / Arch Osteoporos 6:59~155 Crossref Kado DM / 1999 / Vertebral fractures and mortality in older women: a prospective study. Study of Osteoporotic Fractures Research Group / Arch Intern Med 159:1215~1220 Crossref Kannegaard PN / 2010 / Excess mortality in men compared with women following a hip fracture. National analysis of comedications, comorbidity and survival / Age Ageing 39:203~209 Crossref Eriksen EF / 1986 / Normal and pathological remodeling of human trabecular bone: three dimensional reconstruction of the remodeling sequence in normals and in metabolic bone disease / Endocr Rev 7:379~408 Crossref

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