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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background: Breast cancer is one of the most common cancers affecting women and has a high incidence of bone metastasis, causing osteolytic lesions. The elevated expression of receptor activator of nuclear factor-κB ligand (RANKL) in cancer activates osteoclasts, leading to bone destruction. We previously reported that α-tocopheryl succinate (αTP-suc) inhibited interleukin-1-induced RANKL expression in osteoblasts. Here, we examined the effect of αTP-suc on osteolytic bone metastasis in breast cancer. Methods: To examine the effect of αTP-suc on the metastatic capacity of breast cancer, MDA-MB- 231-FL cells were injected into the left cardiac ventricle of BALB/c nude mice along with intraperitoneal injection of αTP-suc. The mice were then analyzed by bioluminescence imaging. To investigate the effect of αTP-suc on osteolysis, 4T1 cells were directly injected into the femur of BALB/c mice along with intraperitoneal injection of αTP-suc. Microcomputed tomography analysis and histomorphometric analysis of the femora were performed. Results: αTP-suc inhibited cell migration and cell growth of 4T1 cells. In line with these results, bone metastasis of MDA-MB-231-FL cells was reduced in mice injected with αTP-suc. In addition, αTP-suc decreased osteoclastogenesis by inhibiting 4T1-induced RANKL expression in osteoblasts. Consistent with these results, 4T1-induced bone destruction was ameliorated by αTP-suc, with in vivo analysis showing reduced tumor burden and osteoclast numbers. Conclusions: Our findings suggest that αTP-suc may be efficiently utilized to prevent and treat osteolytic bone metastasis of breast cancer with dual effects.
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참고문헌 (35)
참고문헌 신청
Roodman GD / 2004 / Mechanisms of bone metastasis / N Engl J Med 350:1655~1664
Coleman RE / 2001 / Metastatic bone disease: clinical features, pathophysiology and treatment strategies / Cancer Treat Rev 27:165~176
Mundy GR / 2002 / Metastasis to bone: causes, consequences and therapeutic opportunities / Nat Rev Cancer 2:584~593
Chen YC / 2010 / Breast cancer metastasis to the bone: mechanisms of bone loss / Breast Cancer Res 12:215
Wang N / 2014 / Prostate cancer cells preferentially home to osteoblast-rich areas in the early stages of bone metastasis: evidence from in vivo models / J Bone Miner Res 29:2688~2696
Coleman RE / 2001 / Metastatic bone disease: clinical features, pathophysiology and treatment strategies / Cancer Treat Rev 27:165~176
Mundy GR / 2002 / Metastasis to bone: causes, consequences and therapeutic opportunities / Nat Rev Cancer 2:584~593
Chen YC / 2010 / Breast cancer metastasis to the bone: mechanisms of bone loss / Breast Cancer Res 12:215
Wang N / 2014 / Prostate cancer cells preferentially home to osteoblast-rich areas in the early stages of bone metastasis: evidence from in vivo models / J Bone Miner Res 29:2688~2696
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