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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 55 - 60 (6page)
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Purpose: We previously demonstrated the following: 1) Magnitude of bone loss and marrow adiposity induced by low calorie diet are greater than those caused by high calorie diet and 2) b-adrenergic (b-AR) blockade mitigates bone loss induced by high calorie diet and marrow adiposity induced by high calorie and low calorie diets. In the present study, we evaluated the levels of leptin in serum and bone marrow to examine whether or not b-AR blockade-induced attenuation of bone loss is associated with leptin.
Materials and Methods: Male 6-week-old C57BL/6 mice were randomly assigned to one of three groups: ad-lib fed control diet (CON), high calorie diet (HIGH), and low calorie diet (LOW). In each diet group, 10 mice were treated with vehicle (VEH) while the other 10 mice were treated with propranolol, a b-AR antagonist (b-blocker; 0.5 g/L).
Results: Serum leptin level was higher in HIGHVEH mice and lower in LOWVEH mice than in CONVEH mice. b-AR blockade did not alter circulating serum leptin levels, but it increased leptin secretion per unit fat mass in high calorie diet-fed mice. Both high calorie and low calorie diets decreased bone marrow leptin expression. b-AR blockade mitigated reduction of bone marrow leptin expression levels seen in mice fed high calorie diet.
Conclusion: These data suggest that the b-AR signaling pathway plays a role in alteration of bone marrow adiposity in response to dietary calorie intake and that leptin is associated with b-AR-mediated regulation of bone and marrow fat.
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참고문헌 (25)
참고문헌 신청
Baek K / 1985 / Blocking β-adrenergic signaling attenuates reductions in circulating leptin, cancellous bone mass, and marrow adiposity seen with dietary energy restriction
Baek K / 2009 / Bloomfield SA: Beta-adrenergic blockade and leptin replacement e ectively mitigate disuse bone loss / J Bone Miner Res 24 : 792 ~ 799
Bjurholm A / 1991 / Neuroendocrine peptides in bone / Int Orthop 15 : 325 ~ 329
Cao JJ / 2011 / Effects of obesity on bone metabolism / J Orthop Surg Res 6 (30)
Ducy P / 2000 / Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass / Cell 100 : 197 ~ 207
Baek K / 2009 / Bloomfield SA: Beta-adrenergic blockade and leptin replacement e ectively mitigate disuse bone loss / J Bone Miner Res 24 : 792 ~ 799
Bjurholm A / 1991 / Neuroendocrine peptides in bone / Int Orthop 15 : 325 ~ 329
Cao JJ / 2011 / Effects of obesity on bone metabolism / J Orthop Surg Res 6 (30)
Ducy P / 2000 / Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass / Cell 100 : 197 ~ 207
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